Serum BUN and creatinine estimation in patients of overt hypothyroidism: a case control study

Authors

  • Bandana Kumari Department of Biochemistry, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India
  • Pawan Kumar Department of CT scan and Ultrasonography, Dev Imaging and Diagnostic Centre, Patna, Bihar, India
  • Jiut R. Keshari Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
  • Arun Kumar Department of Biochemistry, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India
  • Sangeeta Pankaj Department of Gynaecological Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India
  • Radha K. P. Chaudhary Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173968

Keywords:

BUN (blood urea nitrogen), Creatinine, GFR, Hypothyroidism

Abstract

Background: Hypothyroidism or underactive thyroid or low thyroid is a common endocrine disorder characterized by low serum T3 (triiodothyronine), T4 (thyroxine) and raised TSH (thyroid stimulating hormone). Thyroid hormones are involved in renal development and hemodynamic, kidney structure and GFR (glomerular filtration rate). Aim of this study was to see the alteration of basic renal markers in patients of hypothyroidism.

Methods: A total of seventy subjects were included in the study. Thirty-five were patients of hypothyroidism and thirty-five were age and sex matched normal controls. Serum T3, T4, TSH, creatinine and BUN (blood urea nitrogen) were estimated in both groups.

Results: Serum T3, T4 were significantly decreased and TSH was significantly raised among cases as compared to controls. Mean value of serum creatinine and BUN were within normal range in both the groups but these values were significantly raised among cases as compared to controls with p value 0.02 and 0.003 respectively. Also, there was positive correlation of TSH with BUN and creatinine among cases.

Author Biographies

Bandana Kumari, Department of Biochemistry, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India

Department of Biochemistry, Assistant Professor

Pawan Kumar, Department of CT scan and Ultrasonography, Dev Imaging and Diagnostic Centre, Patna, Bihar, India

Department of CT scan and Ultrasonography, Senior Consultant Radiologist.

Jiut R. Keshari, Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India

Department of Biochemistry, Assistant Professor

Arun Kumar, Department of Biochemistry, Vardhman Institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India

Department of Biochemistry, Professor & HOD

Sangeeta Pankaj, Department of Gynaecological Oncology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India

Department of Gynaecological Oncology, Additional Professor & In-charge.

Radha K. P. Chaudhary, Department of Skin and VD, Patna Medical College and Hospital, Patna, Bihar, India

Department of Skin & VD, Professor & HOD

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Published

2017-08-26

How to Cite

Kumari, B., Kumar, P., Keshari, J. R., Kumar, A., Pankaj, S., & Chaudhary, R. K. P. (2017). Serum BUN and creatinine estimation in patients of overt hypothyroidism: a case control study. International Journal of Research in Medical Sciences, 5(9), 3990–3993. https://doi.org/10.18203/2320-6012.ijrms20173968

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Original Research Articles