Depression and COPD-association: not out of the blue

Authors

  • M. Arif Ali Department of Respiratory Medicine, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India
  • Vijay Tukaram Salve Department of Pulmonary Medicine, ESIC Medical College, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20173698

Keywords:

Depression, HAM-D scale, Stable C.O.P.D.

Abstract

Background: Depression is frequently associated with C.O.P.D. patients. Currently available treatment modalities are having limitations and chronic progression of the disease process in general causes decreased effort tolerance and poor socialization due to chronic cough and dyspnoea. Poor socialization and chronic symptoms result in mild depression to dysthymia and clinical depression. Three or more comorbidities associated with C.O.P.D. results in higher morbidity and mortality. Physician treating C.P.O.D. patients can use simple questionnaire based Hamilton depression scale to identify the patients having depressive symptoms.

Methods: 50 diagnosed COPD patients as per GOLD guidelines were enrolled in the study after consideration of inclusion and exclusion criteria. Each patient was screened for depression using 17-point Hamilton depression scale. The results were tabulated and analyzed for statistical significance and compared with the data available on this topic.

Results: Out of 50 stable COPD (diagnosed as per GOLD guidelines) patients enrolled for the study, 36 (72%) were males and 14 (28%) were females and in 19 (38%), (15 males and 4 females) patients HAM-D score was suggestive of depression. 10 (62.5%) patients from severe obstruction category (GOLD III) had mild depressive symptoms on HAM-D scale.

Conclusions: Considering the fact that a significant number of COPD patients enrolled for the study had depressive symptoms, it is advisable to screen the patients for depression and psychiatrist consultations should be considered when required.

References

Di Marco F, Verga M, Reggente M, Casanova FM, Santus P, Blasi F, et al. Anxiety and depression in COPD patients: the roles of gender and disease severity. Respiratory Med. 2006;100(10):1767-74.

van Manen JG, Bindels PJ, Dekker FW, IJzermans CJ, van der Zee JS, Schadé E. Risk of depression in patients with chronic obstructive pulmonary disease and its determinants. Thorax. 2002;57:412-6.

Boden JM, Fergusson DM, Horwood LJ. Cigarette smoking and depression: tests of causal linkages using a longitudinal birth cohort. Br J Psychiatry. 2010;196:440-6.

Atlantis E, Fahey P, Cochrane B, Smith S. Bidirectional associations between clinically relevant depression or anxiety and COPD: a systematic review and meta-analysis. Chest. 2013;144(3):766-77.

Doyle T, Palmer S, Johnson J, Babyak MA, Smith P, Mabe S, et al. Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease. Int J Psych Med. 2013;45(2):189-202.

Dalal AA, Shah M, Lunacsek O, Hanania NA. Clinical and economic burden of depression/anxiety in chronic obstructive pulmonary disease patients within a managed care population. COPD: J Chronic Obstructive Pulmonary Dis. 2011;8(4):293-9.

Kurt BS, Middelboe T, Stage TB, Sørensen CH. Depression in COPD-management and quality of life consideration. Int J COPD. 2006;1(3):315-20.

Yohannes AM, Alexopoulos GS. Depression and anxiety in patients with COPD: Eur Respir Rev. 2014;23(133):345-9.

Marcus R, Munafo, Arya R. Cigarette smoking and depression: a question of causation. Br J Psych. 2010;96:425-6.

Hamilton M. A rating scale for depression. J Neurol Neurosurg Psych. 1960;23(1):56.

Maurer J, Rebbaprsgada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, et al. Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest. 2008;134(4):43S-56S.

Catalfo G, Crea L, Castro TL, San Lio FM, Minutolo G, Siscaro G, et al. Depression, body mass index, and chronic obstructive pulmonary disease: a holistic approach. Int J Chronic Obstructive Pulmonary Dis. 2016;11:239.

Sejal De. Prevalence of depression in stable chronic obstructive pulmonary disease. Ind J Chest Dis Allied Sci. 2011;53:35-9.

Jose AK, Chelangara DP, Shaji KS. Factors associated with anxiety and depression in chronic obstructive pulmonary disease. Int J Res Med Sci. 2016;4:1074-9.

Negi H, Sarkar M, Raval AD, Pandey K, Das P. Presence of depression and its risk factors in patients with chronic obstructive pulmonary disease. Ind J Med Res. 2014;139:402-8.

Schneider C, Jick SS, Bothner U, Meier CR. COPD and the risk of depression. Chest. 2010;137:341-7.

Ljudmila M, Obradovic N, Pesut DP, Maric D, Maskovic J, Maric NP, et al. Symptoms of anxiety and depression in patients with chronic obstructive epulmonary disease. Pneumologia. 2012;61:2.

Tselebis A, Bratis D, Harikiopoulou M, Theodorakopoulou E, Moussas G, Karkanias A, et al. Association between depression and body mass index in patients with chronic obstructive pulmonary disease: International congress on neurobiology and clinical psychopharmacology and European Psychiatric Association conference on treatment guidance Thessaloniki, Greece, 19-22 November 2009. Ann General Psych. 2010;9(1):160.

Elassal G, Elsheikh M, Zeid AG. Assessment of depression and anxiety symptoms in chronic obstructive pulmonary disease patients: a case-control study. Egyptian J Chest Dis Tuberculosis. 2014;63(3):575-82.

Hanania NA, Müllerova H, Locantore NW, Vestbo J, Watkins ML, Wouters EF, et al. Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Res Critical Care Med. 2011;183(5):604-11.

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Published

2017-08-26

How to Cite

Ali, M. A., & Salve, V. T. (2017). Depression and COPD-association: not out of the blue. International Journal of Research in Medical Sciences, 5(9), 3875–3879. https://doi.org/10.18203/2320-6012.ijrms20173698

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Original Research Articles