Delta bilirubin: a sensitive and predictive marker for acute rejection in liver transplant recipients

Authors

  • Deepa Gupta Department of Biochemistry, Medanta the Medicity, Gurgaon, Haryana, India
  • Aditi Gupta Department of Biochemistry, Medanta the Medicity, Gurgaon, Haryana, India
  • Arun Raizada Department of Biochemistry, Medanta the Medicity, Gurgaon, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20180620

Keywords:

Acute rejection, Delta bilirubin, Liver transplantation

Abstract

Background: This study was aimed to investigate the diagnostic utility of delta bilirubin for acute rejection in liver transplant recipients.

Methods: The present study was conducted on 80 patients (56 men and 24 women) who were admitted for a major operation of liver transplantation at super-speciality hospital, Medanta-The Medicity, Gurgaon. The average age of the patients was 43±19 years. Data was analyzed as mean, standard deviation; student t test by using statistical package for social sciences (SPSS) software. Sensitivity, specificity, positive predictive value and negative predictive value were calculated in percentage.

Results: The result from the present study indicates that delta bilirubin had highest sensitivities of 93% whereas conjugated bilirubin has 43% while AST, ALT, GGT and ALKP had sensitivities of 61%, 81%, 80% and 31% respectively. There was a significant difference of delta bilirubin between rejection and non rejection transplant recipients.

Conclusions: Our findings supported that the serial measurement of delta bilirubin would be a reliable marker for recognizing early rejection in liver transplant recipients.

References

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Published

2018-02-22

How to Cite

Gupta, D., Gupta, A., & Raizada, A. (2018). Delta bilirubin: a sensitive and predictive marker for acute rejection in liver transplant recipients. International Journal of Research in Medical Sciences, 6(3), 945–949. https://doi.org/10.18203/2320-6012.ijrms20180620

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Original Research Articles