Sister Mary Joseph nodule due to carcinosarcoma

Israel Salgado Adame


The Sister Mary Joseph Nodule is an eponymous term which describes a palpable umbilical nodule occurring as a result of metastasis of an intra-abdominal or pelvic malignancy. In approximately 50% of cases, this sign is associated with gastrointestinal malignancies. These include gastric, colonic and pancreatic (mainly body and tail) carcinoma. Gastrointestinal malignancy is found in 52% of the metastatic cases and gynecologic and genitourinary origin in 28%, with gastric and ovarian cancers being the most common. The next report is about a 62 year-old woman whose was referred to the surgery department due a painful mass on the abdominal wall that has appeared 3 months before as a fast-growing, with suspicious diagnosis of strangulated umbilical hernia.


Sister Mary Joseph, Nodule, Carcinosarcoma, Malignancy, Metastasis

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Sethi K, Shareef N, Bloom S. The Sister Mary Joseph nodule. Br J Hosp Med. 2018;79(2):C27-9.

Segovis CM, Dyer RB. The "Sister Mary Joseph Nodule". Abdom Radiol. 2017;42(5):1610-1.

Dubreuil A, Dompmartin A, Barjot P, Louvet S, Leroy D. Umbilical metastasis or Sister Mary Joseph’s nodule. International Journal of Dermatology. 1998;37(1):7-13.

Yang M, Hopp AC, Bekaii-Saab TS, Collins JM. Sister Mary Joseph Nodule in Advanced Pancreatic Adenocarcinoma Identified on 18F-FDG PET/MRI. J Nucl Med Technol. 2019;47(4):341-2.

Denschlag D, Ulrich UA. Uterine Carcinosarcomas - Diagnosis and Management. Oncol Res Treat. 2018;41(11):675-9.

Sherman ME, Devesa SS. Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus. Cancer. 2003;98(1):176-86.

Hosh M, Antar S, Nazzal A, Warda M, Gibreel A, Refky B. Uterine Sarcoma: Analysis of 13,089 Cases Based on Surveillance, Epidemiology, and End Results Database. Int J Gynecol Cancer. 2016;26(6):1098-104.

Wongrakpanich S, Patnaik S, Morginstin M. An umbilical nodule in a patient with enlarged uterus. Eur J Intern Med. 2016;27:e3-4.

Gurumurthy M, Somoye G, Cairns M, Parkin DE. An update on the management of uterine carcinosarcoma. Obstet Gynecol Surv. 2011;66(11):710-6.

Barboza-Quintana O, Alvarado-Bernal YL, Flores-Gutiérrez JP, Ancer-Rodríguez J, Garza-Guajardo R. Diagnosis of carcinosarcoma metastatic to the umbilicus by fine needle aspiration biopsy: a case report. Acta Cytol. 2010;54(5):819-22.