Published: 2021-08-25

Comparative analysis of quantitative dermatoglyphic markers in schizophrenia patients and controls attending a superspeciality hospital in West Bengal

Amit Kumar Pal, Sagarika Ray, Jishnu Bhattacharya


Background: Schizophrenia is a psychiatric disorder encompassing multiple etiological variables. Association of dermatoglyphic traits with schizophrenia has been observed and reported. This study was undertaken to evaluate epidermal ridge patterns in patients of schizophrenia as compared to healthy controls attending a superspeciality hospital in West Bengal. Establishing dermatoglyphic parameters as biomarkers for early diagnosis will ensure prompt intervention and a greater scope of recovery in schizophrenia and thus promote a better quality of life for the individual as well as lower the burden of disease for the society.

Methods: Quantitative dermatoglyphic parameters namely, total finger ridge count (TFRC), total A-B ridge count (TABRC) and ATD angle of 50 schizophrenia patients were compared to 50 age and gender matched healthy controls.

Results: TFRC and TABRC were found to be decreased in schizophrenia, while ATD angle was increased in schizophrenia as compared to the control group.

Conclusions: This study found a significant association between dermatoglyphic pattern anomalies and the development of schizophrenia. This may offer a scope of primordial prevention of schizophrenia in future, utilising dermatoglyphics as an investigative tool.


Schizophrenia, Dermatoglyphics, Epidermal ridge, Total finger ridge count, Total A-B ridge count, ATD angle

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Venkatesh E, Anjana B, Keluskar V, Shetti A. Palmar dermatoglyphics in oral leukoplakia and oral squamous cell carcinoma patients. J Indian Acad Oral Med Radiol. 2008;20(3):94-9.

Kiran K, Kavitha R, Amitha HM. Dermatoglyphics as a non-invasive diagnostic tool in predicting mental retardation. J Int Oral Health. 2010;2(1):95-100.

Newman HH. Methods of printing: ink method. In: Cummins H, Midlo C, eds. Finger prints of palms and soles: an introduction to dermatoglyphics. 1st ed. Philadelphia, PA: Blakiston Company; 1943: 45.

Wertheim K. Embryology and morphology of friction ridge skin. The Fingerprint Sourcebook. Washington: National Institute of Justice; 2002.

The ICD-10 classification of mental and behavioural disorders-clinical descriptions and diagnostic guidelines. World Health Organization, 76-91. Available at: Accessed on 3 March 2021.

Tamminga CA. Schizophrenia and other psychotic disorders: Introduction and overview. In: Sadock BJ, Sadock VA, Kaplan RP, eds. Sadock’s Comprehensive Textbook of Psychiatry. 10th ed. Philadelphia: Wolters Kluwer; 2017.

Perez JM, Ghose S. Schizophrenia and other psychotic disorders: Cellular and molocular neuropathology of schizophrenia. In: Sadock BJ, Sadock VA, Ruiz P. Kaplan RP, eds. Sadock’s Comprehensive Textbook of Psychiatry. 10th ed. Philadelphia: Wolters Kluwer; 2017.

Lavretsky H. History of schizophrenia as a psychiatric disorder. In: Mueser KT, Jeste DV, eds. Clinical Handbook of Schizophrenia. New York: Guilford Press; 2008: 3-12.

Murray M, Lewis SW. Is schizophrenia a neurodevelopmental disorder? Br Med J (Clin Res Ed). 1987;295(6600):681-2.

Os JV, Woodruff PW, Fañanas L, Ahmad F, Shuriquie N, Howard R, et al. Association between cerebral structural abnormalities and dermatoglyphic ridge counts in schizophrenia. Comprehens Psych. 2000;41(5):380-4.

Fearon, P, Lane A, Airie M, Scannell J, McGowan A, Byrne M, et al. Is reduced dermatoglyphic a-b ridge count a reliable marker of developmental impairment in schizophrenia? Schizophr Res. 2001;50(3):151-7.

Waterworth DM, Bassett AS, Brzustowicz LM. Recent advances in the genetics of schizophrenia. Cell Mol Life Sci. 2002;59(2):331-48.

Mednick SA, Machon RA, Huttunen MO, Bonett D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry. 1988;45(2):189-92.

Fatjó-Vilas M, Gourion D, Campanera S, Mouaffak F, Levy-Rueff M, Navarro ME, et al. New evidences of gene and environment interactions affecting prenatal neurodevelopment in schizophrenia-spectrum disorders: a family dermatoglyphic study. Schizophr Res. 2008;103(1-3):209-17.

Norovsambuu O, Tsend-Ayush A, Lkhagvasuren N, Jav S. Main characteristics of dermatoglyphics associated with schizophrenia and its clinical subtypes. PLoS ONE. 2021;16(6):e0252831.

Kendall KM, Owen MJ. Schizophrenia and other psychotic disorders: genetics of schizophrenia. In: Sadock BJ, Sadock VA, Kaplan RP, eds. Sadock’s Comprehensive Textbook of Psychiatry. 10th ed. Philadelphia: Wolters Kluwer; 2017.

Rees E, Walters JT, Georgieva L, Isles AR, Chambert KD, Richards AL, et al. Analysis of copy number variations at 15 schizophrenia-associated loci. Br J Psychiatry. 2014;204(2):108-14.

Rees E, Kendall K, Pardiñas AF, Legge SE, Pocklington A, Escott-Price V, et al. Analysis of intellectual disability copy number variants for association with schizophrenia. JAMA Psychiatry. 2016;73(9):963-9.

Hall J, Trent S, Thomas KL, O'Donovan MC, Owen MJ. Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity. Biol Psychiatry. 2015;77(1):52-8.

Cooper J. Schizophrenia: the epigenetic puzzle. British J Psychiat. 1983;143(2):213-4.

Harrison P, Weinberger D. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10:40-68.

Rujescu D, Ingason A, Cichon S, Pietiläinen OPH, Barnes MR, Toulopoulou T, et al. Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet. 2009;18(5):988-96.

Purcell S, Moran J, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90.

Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373(9659):234-9.

Kendler K, Gardner CO. The risk for psychiatric disorders in relatives of schizophrenic and control probands: a comparison of three independent studies. Psychol Med. 1997;27(2):411-9.

Sullivan PF, Daly MJ, O'Donovan M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet. 2012;13(8):537-51.

Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60(12):1187-92.

Tienari P, Wynne LC, Läksy K, Moring J, Nieminen P, Sorri A, et al. Genetic boundaries of the schizophrenia spectrum: evidence from the Finnish adoptive family study of schizophrenia. Am J Psychiatry. 2003;160(9):1587-94.

Holt SB. Clinical review: the significance of dermatoglyphics in medicine a short survey and summary. Clin Pediatr (Phila). 1973;12(9):471-84.

Mellor CS. Dermatoglyphic evidence of fluctuating asymmetry in schizophrenia. Br J Psychiatry. 1992;160(4):467-72.

Ponnudurai R. Relevance of sequential development of dermatoglyphics to schizophrenia. Psychiatry Res. 1999 Dec 13;89(1):59-67.

Bramon E, Walshe M, McDonald C, Martín B, Toulopoulou T, Wickham H, et al. Dermatoglyphics and schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count. Schizophr Res. 2005;75(2-3):399-404.

Avila MT, Sherr J, Valentine LE, Blaxton TA, Thaker GK. Neurodevelopmental interactions conferring risk for schizophrenia: a study of dermatoglyphic markers in patients and relatives. Schizophr Bull. 2003;29(3):595-605.

Fananas L, Os JV, Hoyos C, McGrath J, Mellor CS, Murray R. Dermatoglyphic A-B ridge count as a possible marker for developmental disturbance in schizophrenia: replication in two samples. Schizophr Res. 1996;20(3):307-14.

Murthy RS, Wig NN. Dermatoglyphics in schizophrenia: the relevance of positive family history. Br J Psychiatry. 1977;130(1):56-8.

Jhingan H, Munjal G. Dermatoglyphics In Female Catatonic Schizophrenics. Indian J Psychiatry. 1989;31(4):329-32.

Sengupta S, Bhuyan SD. Palmar dermatoglyphics in schizophrenia. Indian J Psychiatry. 1995;37(2):86-90.

Fearon P, Lane A, Airie M, Scannell J, McGowan A, Byrne M, et al. Is reduced dermatoglyphic a-b ridge count a reliable marker of developmental impairment in schizophrenia. Schizophr Res. 2001;50(3):151-7.

Ozyurt B, Songur A, Sarsilmaz M, Akyol O, Namli M, Demirel R. Dermatoglyphics as markers of prenatal disturbances in schizophrenia: a case- control study. Turk J Med Sci. 2010;40(6):917-24.

Latiff AA, Sundarapandian S, Saravanan R. (2017). A comparative study of dermatoglyphic markers in schizophrenia patients and normal controls. Int J Res Med Sci. 2017;5(6):2558-62.