DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20214410

Profile of COVID-19 patients in COVID dedicated tertiary care centre in Himachal Pradesh: a prospective observational cross sectional study

Roshan Lal, Rajesh K. Bhawani, Santosh K. Dheer, Nitesh Kumar, Soni Kumar

Abstract


Background: COVID-19 pandemic originated in China in December 2019 and fumed in whole world over few months. Millions of deaths have occurred worldwide till now because of this pandemic. Causative agent was identified as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causing viral pneumonia and serious manifestations were seen in association with increased age and comorbidies.

Methods: This study was planned in very initial stage of pandemic in our country to study the profile of COVID-19 patients. This study was conducted over a period of six months from April 2020 to September 2020 at SLBSGMCH, Mandi at Nerchowk.

Results: 202 patients were enrolled for this study with mean age of presentation 48 years, 61 were females, 147 (72%) were senior citizens, most patients were from district Mandi and most common symptoms were fever (58%), cough (46%), shortness of breath (35%) and associated commonest comorbidities were hypertension (HTN) (29%) and diabetes (23%). Median neutrophil to lymphocyte ratio (NLR) was higher (5.47) in moderate to severe disease and associated with poor outcome. All the 11 patients who were put on support of ventilator, succumbed to death.

Conclusions: Most common symptoms were fever, cough, shortness of breath and most common comorbidty was HTN. Comorbidity, increased age and higher NLR were risk factors for severity and poor outcome. More research is needed to save mankind from this pandemic as still no specific therapy is available against this virus.


Keywords


Corona virus disease, Rapid antigen test, Real time polymerized chain reaction

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References


Cennimo DJ. Coronavirus Disease 2019 (covid-19). Medscape. 2020. Available at: https://emedicine. medscape.com/article/2500114-overview. Accessed on 23 May 2021.

Gallegos A. WHO Declares Public Health Emergency for Novel Corona virus. Medscape Medical News. 2020. Available at: https://www. medscape.com/viewarticle/924596. Accessed on 23 May 2021.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33.

World Health Organization. Novel coronavirus (2019-nCoV) situation report - 6. 2020. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports. Accessed on 23 May 2021.

Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-51.

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-81.

Kayina CA, Haritha D, Soni L, Behera S, Nair PR, Gauri K, et al. Epidemiological & clinical characteristics & early outcome of COVID-19 patients in a tertiary care teaching hospital in India: A preliminary analysis. Indian J Med Res. 2020;152(1):100-4.

Zhang H, Shang W, Liu Q, Zhang X, Zheng M, Yue M. Clinical characteristics of 194 cases of COVID-19 in Huanggang and Taian, China. Infection. 2020;48(5):687-94.

Bhandari S, Bhargava A, Sharma S,Keshwani P, Sharma R, Banerjee S, et al. Clinical Profile of Covid-19 Infected Patients Admitted in a Tertiary Care Hospital in North India. J Assoc Physicians India. 2020;68(5):13-7.

Ciccullo A, Borghetti A, Zileri Dal Verme L, Tosoni A, Lombardi F, Garcovich M, Biscetti F, Montalto M, Cauda R, Di Giambenedetto S; GEMELLI AGAINST COVID Group. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020;56(2):106017 .

Shukla UB, Shukla SR, Palve SB, Yeravdekar RC, Natarajan VM, Tiwari P, Yajnik CS. Characteristics of COVID-19 Patients Admitted to a Tertiary Care Hospital in Pune, India and Predictors of Requirement for Intensive Care Treatment. J Assoc Physicians India. 2021;69(7):11-2.

CDC COVID-19 Response Team. Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(12):343-6.

King CS, Sahjwani D, Brown AW, Feroz S, Cameron P, Osborn E, et al. Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure. PLoS One. 2020;15(11):e0242651.