Published: 2021-09-28

Correlation between cholesterol levels and the severity of Parkinson disease

Sandy Kumala, Rizal Tumewah, Sekplin A. S. Sekeon


Background: Parkinson disease is the second most common neurodegenerative disease after dementia Alzheimer. In neurodegenerative disease such as PD, there is a disturbance of cholesterol metabolism in the brain that could affect plasma cholesterol level. Laboratory test of cholesterol level could be used as an alternative parameter in assessing the severity degree of PD. Our objectives in this study are to analyze the correlation between cholesterol level and the severity of PD. 

Methods: This study is a cross sectional study. The sample is collected from patients with PD that came too neurology clinic in Prof Dr. R. D. Kandou Manado Hospital. Patients will then be assessed whether they meet the inclusion criteria which is examined using unified Parkinson disease rating scale (UPDRS) questionnaire and Hoehn and Yahr (H and Y). If the inclusion criteria are met, subject will be tested for total cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL) levels in plasma.

Results: There are 60 subjects of PD patients with mean age 64.37±8.26 years old. Male subjects were more dominant (53.3%) than female. Total cholesterol level and LDL have moderate negative correlation with UPDRS I, UPDRS II, UPDRS III, and UPDRS total score. Total cholesterol and LDL level also has moderate negative correlation with H and Y severity.

Conclusions: There is a moderate negative correlation between total cholesterol level and LDL with PD severity degree based on H&Y degree and UPDRS I, II, III, and UPDRS total score. 


Cholesterol level, UPDRS, H and Y, Parkinson disease

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