Adaptogenic potential of Centella lujica supplement in sleep deprived mice

Authors

  • Anthony T. Eduviere Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
  • Prosper E. Awhin Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
  • Kesiena E. Edje Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
  • Lily O. Otomewo Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria
  • Olusegun A. Adeoluwa Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medicine and Health Sciences, Afe Babalola University Ado Ekiti, Ekiti State, Nigeria
  • Jennifer E. Winter Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20214408

Keywords:

Stress, Centella lujica, Sleep deprivation, Adaptogenic, Oxidative stress

Abstract

Background: Stress, whether internal or external, has been shown to play a role in the accumulation of oxidative free radicals which leads to cellular modification of normal organ or body function. Centella lujica (C. lujica) is a commonly cultivated herb with therapeutic benefits in various studies. This study aims to evaluate its beneficial effect on the brain and liver of mice exposed to sleep deprivation-induced stress.

Methods: Albino mice were treated with distilled water (control), C. lujica (50 and 100 mg/kg) or astaxanthin (50 mg/kg) for seven days. All groups except control were then subjected to three-days of sleep deprivation using the grid suspended over water model beginning from day 4 of treatment. Behavioural assessments followed by biochemical assays and histological analysis were carried out thereafter.

Results: Sleep deprivation caused an increase in blood glucose and triglycerides levels but reduced high density lipoproteins. Brain pro-oxidant levels were increased with a concomitant decrease in antioxidants, recognition memory was diminished while depressive-like symptoms were enhanced and neuronal viability of hippocampal CA1 as well as prefrontal cortex cells was reduced in sleep-deprived mice. However, supplementation with C. lujica reversed these effects as significantly as astaxanthin.

Conclusions: C. lujica possesses antioxidant property that makes it an effective adaptogen against stress induced responses in mice.

 

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Published

2021-10-28

How to Cite

Eduviere, A. T., Awhin, P. E., Edje, K. E., Otomewo, L. O., Adeoluwa, O. A., & Winter, J. E. (2021). Adaptogenic potential of Centella lujica supplement in sleep deprived mice. International Journal of Research in Medical Sciences, 9(11), 3269–3276. https://doi.org/10.18203/2320-6012.ijrms20214408

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Original Research Articles