Correlative study of diabetic retinopathy in type 2 diabetes mellitus with haemoglobin A1c, duration of diabetes and modifiable risk factors: smoking, alcohol and BMI in adult population attending a tertiary care hospital

Nutan Bedi; Archana O. Gulati; Gauri V. Devasthali

doi:10.18203/2320-6012.ijrms20213663

Authors

Nutan Bedi Department of Ophthalmology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
Archana O. Gulati Department of Ophthalmology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
Gauri V. Devasthali Department of Ophthalmology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20213663

Keywords:

Diabetes, HbA1c, Diabetic retinopathy, Alcohol, Smoking, BMI

Abstract

Background: Diabetes is a disease, which if not controlled, affects every cell of the body from head to toe. No wonder it is often referred to as the “SILENT KILLER”. So through our study, we aim to study the correlation between (haemoglobin A1c) HbA1c levels, duration of diabetes and modifiable risk factors with diabetic retinopathy (DR) in patients of type 2 diabetes mellitus.

Methods: This study was conducted in 100 patients (200 eyes) who were diagnosed cases of type 2 diabetes mellitus. A detailed history of the duration of diabetes, alcohol intake and smoking and HbA1c levels was taken. Complete ocular examination was done. BMI was also calculated.

Results: 2/3rd of the eyes with grade 3 DR were of>10 years duration while 2/3rd of the eyes with grade 2 DR were of 5-10 years duration. Of the eyes with grade 3 DR, all the patients had HbA1c of more than 8. Significant p value shows strong correlation between DR and obesity. No significant correlation of DR was found with alcohol and smoking.

Conclusions: The findings in our study endorse the view that duration and HbA1c are important risk factors for occurrence and severity of DR and therefore a regular follow up and good glycemic control is highly essential for the prevention of occurrence and progression of DR. Strong correlation between BMI and DR suggest that lifestyle changes play a pivotal role.

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References

Ryan SJ. Retina. Medical Retina. 5th ed. Philadelphia: Elsevier; 2013: 925-939.

Skuta GL, Cantor LB, Weiss JS. Basic and clinical science course, retina and vitreous. Am Aca Ophthalmol. 2011:167-8.

Bowling B. In: Kanski JJ, Bowling B, eds. Kanski's clinical ophthalmology: a systematic approach. 8th ed. Saunders ltd; 2015: 520-77.

Singh R, Prakash V, Shukla PK, Gautam S, Maurya OP. Glycosylated hemoglobin and diabetic retinopathy. Ann Ophthalmol. 1991;23(8):308-11.

Apoorva, Devendra J. Study of correlation of blood levels of haemoglobin A1c to the presence of diabetic retinopathy in patients with type II diabetes mellitus. Indian J Basic Appl Med Res. 2017;6(4):552-7.

Garg P, Misra S, Yadav S, Singh L. Correlative study of diabetic retinopathy with HbA1c and microalbuminuria. Int J Ophthal Res. 2018;4(2):282-6.

Gadkari SS, Maskati QB, Nayak BK. Prevalence of diabetic retinopathy in India: all India ophthalmological society diabetic retinopathy eye screening study 2014. Indian J Ophthalmol. 2016;64(1):38.

Shrote AP, Diagavane S. Clinical evaluation of correlation between diabetic retinopathy with modifiable, non-modifiable and other independent risk factors in tertiary set-up in central rural India. J Clinic Diagnos Res. 2015;9(10):10.

Young RJ, McCulloch DK, Prescott RJ, Clarke BF. Alcohol: another risk factor for diabetic retinopathy? Br Med J. 1984;288(6423):1035-7.