Male sex hormone as a correlate of endothelial function in middle-aged Indian males: a cross-sectional prospective observational study

Authors

  • Chandra Mohan Department of Cardiology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Kunal Gururani Department of Cardiology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Anurag Rawat Department of Cardiology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India
  • Mansi Kala Department of Pathology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20214844

Keywords:

Brachial artery, Dysfunction, Endothelium, Risk factor, Testosterone

Abstract

Background: Data on relationship between serum testosterone and endothelial dysfunction measured by brachial artery flow-mediated dilatation (BAFMD) in Indian subset are scarce. The present study was envisaged to assess the correlation between serum testosterone and endothelial dysfunction measured by BAFMD.

Methods: From October 2013 till September 2014, 92 Indian male patients aged 40-60 years who underwent investigation of flow-mediated dilatation of the brachial artery using ultra sonography were included. The association between serum testosterone and BAFMD percent-measured endothelial dysfunction was examined.

Results: Multivariate regression analysis in 92 Indian male patients (mean age 53.12±6.3 years) revealed that low levels of total serum, serum free and serum bioavailable testosterone were significantly associated with BAFMD% and were independent of age, hypertension, diabetes, body mass index (BMI), current smoking and hyperlipidaemia (p<0.001). The total serum, serum free and serum bioavailable testosterone were positively correlated with BAFMD% with Pearson correlation coefficients of r=0.572, r=0.525 and r=0.547, respectively (p<0.001).

Conclusions: Low levels of total serum, serum free and serum bioavailable testosterone were significantly associated with BAFMD%-measured endothelial dysfunction, irrespective of cardiovascular risk factors.

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Published

2021-12-28

How to Cite

Mohan, C., Gururani, K., Rawat, A., & Kala, M. (2021). Male sex hormone as a correlate of endothelial function in middle-aged Indian males: a cross-sectional prospective observational study. International Journal of Research in Medical Sciences, 10(1), 53–58. https://doi.org/10.18203/2320-6012.ijrms20214844

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Original Research Articles