Ileal perforation caused by cytomegalovirus in an immunocompetent patient

Gloria M. Guzman, Cinthia Olvera, Jose G. Sevilla, Carlos Lopez, Karen Huerta


Cytomegalovirus (CMV) is a subclinical infection that causes catastrophic consequences for patients, specifically those who are immunocompromised. In this article we review a 71-year-old male patient with history of ischemic cardiopathy, he begins with abdominal pain localized in right inferior quadrant. The abdominopelvic CT scan reported an acute complicated appendicitis with pneumoperitoneum. We realized a laparotomy, identifying an ileal perforation. CMV diagnosis was made by histological findings.


CMV, Ileal perforation, CMV enteritis

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Kato K, Cooper M. Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant. BMJ Case Rep. 2019;12(11):e231662.

Bang S, Park YB, Kang BS, Park MC, Hwang MH, Kim HK, Lee SK. CMV enteritis causing ileal perforation in underlying lupus enteritis. Clin Rheumatol. 2004;23(1):69-72.

Meza AD, Bin-Sagheer S, Zuckerman MJ, Morales CA, Verghese A. Ileal perforation due to cytomegalovirus infection. J Natl Med Assoc. 1994;86(2):145-8.

Kawate S, Ohwada S, Sano T, Kawashima Y, Kishikawa I, Tomizawa N et al. Ileal perforation caused by cytomegalovirus infection in a patient with recurrent gastric cancer: report of a case. Surg Today. 2002;32(12):1088-90.

Cha JM, Lee JI, Choe JW, Joo KR, Jung SW, Shin HP et al. Cytomegalovirus enteritis causing ileal perforation in an elderly immunocompetent individual. Yonsei Med J. 2010;51(2):279-83.

Chamberlain RS, Atkins S, Saini N, White JC. Ileal perforation caused by cytomegalovirus infection in a critically ill adult. J Clin Gastroenterol. 2000;30(4):432-5.

Kram HB, Shoemaker WC. Intestinal perforation due to cytomegalovirus infection in patients with AIDS. Dis Colon Rectum. 1990;33(12):1037-40.

Vilaichone RK, Mahachai V, Eiam-Ong S, Kullavanuaya P, Wisedopas N, Bhattarakosol P. Necrotizing ileitis caused by cytomegalovirus in patient with systemic lupus erythematosus: case report. J Med Assoc Thai. 2001;84(1):S469-73.

Krech U. Complement-fixing antibodies against cytomegalovirus in different parts of the world. Bull World Health Organ. 1973;49(1):103-6.

Cohen JI, Corey GR. Cytomegalovirus infection in the normal host. Medicine (Baltimore). 1985;64(2):100-14.

Hinnant KL, Rotterdam HZ, Bell ET, Tapper ML. Cytomegalovirus infection of the alimentary tract: a clinicopathologic correlation. Am J Gastroenterol. 1986;73:37-44.

Nishimura T, Nakao A, Okamoto A, Kihara T, Hirota S, Fujisaki N et al. Ileum perforation due to cytomegalovirus infection in a patient with adult T-cell leukemia. Acute Med Surg. 2015;3(2):178-81.