Compliance, efficacy and quality of life for oral morphine versus transdermal fentanyl patch in management of cancer pain

Authors

  • Gauridas Singha N. Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India
  • Arun Deka Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India
  • Dipankar Dakua Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20220515

Keywords:

Transdermal fentanyl, Morphine, Chronic pain, Cancer, Opioid analgesics

Abstract

Background: A randomized, open, two-period, crossover study was done on cancer patients requiring strong opioid analgesia (n=104, mean age 63.5, range18-83 years) recruited from State Cancer Institute, Gauhati Medical College and Hospital, comparing transdermal fentanyl with oral morphine.

Methods: Patients received one treatment for 15 days followed immediately by the other for 15 days.

Results: Transdermal fentanyl provided good pain relief and it was also was associated with less constipation when compared to oral morphine(p<0.05). Of those who were able to express a preference, significantly more preferred fentanyl patches.

Conclusions: Transdermal fentanyl patch provided good pain relief, equivalent to that provided by oral morphine, required lesser rescue doses, improved quality of life and is associated with less constipation when compared to morphine, and was preferred more by patients.  

Author Biographies

Gauridas Singha N., Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India

Fellow, Certificate Course in Pain and Palliative  Care

Department of Pain and palliative Medicine, State Cancer Institute, Gauhati Medical College and Hospital, Guwahati, Assam

Arun Deka, Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India

Associate Professor and Consultant

Department of Pain and palliative Medicine, State Cancer Institute, Gauhati Medical College and Hospital, Guwahati, Assam

Dipankar Dakua, Department of Pain and Palliative Care, State Cancer Institute, Guwahati Medical College and Hospital, Assam, India

Medical Officer

Department of Pain and palliative Medicine, State Cancer Institute, Gauhati Medical College and Hospital, Guwahati, Assam

 

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Published

2022-02-25

How to Cite

N., G. S., Deka, A., & Dakua, D. (2022). Compliance, efficacy and quality of life for oral morphine versus transdermal fentanyl patch in management of cancer pain. International Journal of Research in Medical Sciences, 10(3), 666–670. https://doi.org/10.18203/2320-6012.ijrms20220515

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Section

Original Research Articles