Histomorphological spectrum of central nervous system lesions in a tertiary care hospital


  • Hetal Kirit Shah Pravara institute of medDepartment of Pathology, Rural Medical College, Pravara Institute of Medical Sciences (DU), Maharashtra, India ical sciences
  • Suryakant Dongre Department of Pathology, Rural Medical College, Pravara Institute of Medical Sciences (DU), Maharashtra, India
  • Ravindra Karle Department of Pathology, Rural Medical College, Pravara Institute of Medical Sciences (DU), Maharashtra, India




CNS lesions, CNS tumors, Histopathological


Background: Central nervous system (CNS) lesions show considerable geographic and racial variations with respect to the incidence and their pattern of distribution. CNS neoplasm account for 2% of all cancers. There has been a rapid increase in incidence of CNS tumors. Many non-neoplastic CNS lesions can clinically and radiologically mimic brain tumors and to differentiate them histopathological examination is necessary.

Methods: This was a descriptive cross-sectional study of 30 cases, carried out from March 2020 to February 2021, in a tertiary health care hospital. The cases were diagnosed histopathologically and categorized according to the WHO 2021 classification.

Results: The study included 30 cases. 3 (10%) of them were non-neoplastic while 27 (90%) were neoplastic with glioblastoma and diffuse astrocytoma being the most common. Overall, tumors of neuroepithelial tissue (60%) was the most common entity. Frontal lobe was the most commonly observed site in the neoplastic lesion. Headache was the most common presentation. Age range varied from 7 years to 66 years with the mean age of 32.7 years.

Conclusions: The spectrum of neoplastic lesions were astrocytoma, glioblastoma, ependymoma, hemagioblastoma, medulloblastoma, meningioma, non-hodgkins lymphoma, oligodendroglioma, pitutary adenoma, schwannoma and non-neoplastic were A-V malformation, brain abscess, subdural empyema.


Rathod V, Bhole A, Chauhan M, Ramteke H, Wani B. Study of clinico-radiological and clinico-pathological correlation of intracranial space occupying lesion at rural center. J Neurosurg. 2009;7(1).

Khonglah Y, Shangpliang D, Mishra J, Mustafa A, Kakoti A, Phukan P. Histological spectrum of central nervous system lesions at a tertiary care center in India. Clin Cancer Investig J. 2020;9(5):175-81.

Joshi H, Awasthi S, Dutta S, Bhardwaj R. Histopathological spectrum of central nervous system lesions. Trop J Path Micro. 2019;5(11):844-9.

Allen P, Liu G. Primary brain tumors in adults: diagnosis and treatment. Am Acad Fam Phys. 2016;93(3):211-7.

Lee CH, Jung KW, Yoo H, Park S, Lee SH. Epidemiology of primary brain and central nervous system tumors in Korea. J Korean Neurosurg Soc. 2010;48(2):145-52.

Aryal G. Histopathological pattern of central nervous system tumor: a three-year retrospective study. J Pathol Nepal. 2011;1:22-5.

Desai RI, Soni NS, Desai IM, Rajput K. Retrospective study of CNS tumors in tertiary care hospital. In Int J Cur Res Rev. 2017;9(2).

Nibhoria S, Tiwana KK, Phutela R, Bajaj A, Chhabra S, Bansal S. Histopathological spectrum of central nervous system tumors: a single centre study of 100 cases. Int J Sci Stud. 2015;3(6):130-4.

Vimal S, Dharwadker A, Vishwanathan V, Agarwal N. Histopathological spectrum of central nervous system tumours in a tertiary care centre. Indian J Pathol Res Pract. 2020;9(2):103-10.

Jaiswal J, Shastry AH, Ramesh A, Chickabasaviah YT, Arimappamagan A, Santosh V. Spectrum of primary intracranial tumours at a tertiary care neurological institute: a hospital-based brain tumor registry. Neurol India. 2016;64:494-501.

Thakur AS, Gahine R, Kulkarni V. A study on morphologic and histological pattern of the central nervous system tumors. Int J Res Med Sci. 2018;6(12):3879-82.

Mohammed AA, Hamdan AN, Homoud AS. Histopathological profile of brain tumors: A 12-year retrospective study from Madinah, Saudi Arabia. Asian J Neurosurg. 2019;14(4):1106-11.

Mehta J, Bansal B, Mittal A, Mathur K, Vijay R. Histological analysis of primary brain tumors in a tertiary care hospital: a retrospective study of 5 years. Int J Med Res Prof. 2017;3(5):14-8.

Hamdani SM, Dar NQ, Reshi R. Histopathological spectrum of brain tumors: a 4-year retrospective study from a single tertiary care facility. Int J Med Sci Public Health. 2019;8(8):673-6.

Adnan HA, Kambhoh UA, Majeed S. Frequency of CNS lesions in a tertiary care hospital-a 5-year study. Biomedica. 2017;33(1):4-8.

Masoodi T, Gupta RK, Singh JP, Khajuria A. Pattern of central nervous system neoplasms: A study of 106 cases JK-practitioner. 2012;17(4).

Lakshmi K, Hemalatha M, Tamil Arasi DS, Rao B. Histopathological study of spectrum of the lesions of central nervous system in a tertiary care hospital. J Evol Med Dent Sci. 2015;4(7):1145-50.

Sumathi V, Balakrishnan K, Krishna MSS. Histopathological spectrum and grading of CNS tumours in tertiary centre: case study of 83 cases. J Evid Based Med Healthc. 2016;3(45):2240-3.

Pidakala P, Inuganti RV, Boregowda C, Mathi A, Lakhineni S. A five-year histopathological review of CNS tumours in a tertiary centre with emphasis on diagnostic aspects of uncommon tumours. J Evid Based Med Healthc. 2016;3(51):2605-12.

Kalyani D, Rajyalakshmi S, Kumar O. Clinicopathological study of posterior fossa intracranial lesions. J Med Allied Sci. 2014;4(2):62-8.

Benjarge PV, Kulkarni A. Clinical profile of intracranial space occupying lesions of the brain. IMJ. 2014;1:288-92.

Mahmoud MZ. Intra cranial space occupying lesions in Saudi patients using computed tomography. Asian J Med Radial Res. 2013;1:25-8.




How to Cite

Shah, H. K., Dongre, S., & Karle, R. (2021). Histomorphological spectrum of central nervous system lesions in a tertiary care hospital. International Journal of Research in Medical Sciences, 10(1), 86–91. https://doi.org/10.18203/2320-6012.ijrms20215036



Original Research Articles