DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20220292

A cross-sectional study of neutrophil to lymphocyte ratio as a reliable inflammatory index among hypertensives in Government Rajaji Hospital, Madurai

Poihai A., Sivapriya A.

Abstract


Background: Hypertension is a major risk factor to the development of atherothrombosis which is of major health concern today. Neutrophils and platelets play a significant role in the development of atherothrombosis leading to cardiovascular events. Presently, neutrophil lymphocyte ratio and platelet lymphocyte ratio which can be easily calculated from complete blood count have been identified as novel systemic inflammation based indices predictive of cardiovascular risk. This study attempted to assess the relationship between neutrophil lymphocyte ratio and platelet lymphocyte ratio with hypertension.

Methods: This cross-sectional study was conducted in 30 hypertensive patients with less than 2 years of duration and in 30 normal healthy adults between ages 40 to 60 years. Anthropometric measurements (height, weight) and blood pressure were measured. Complete blood count was also analyzed. Pearson’s correlation factor (r) was used to analyse quantitative data.

Results: Both neutrophil lymphocyte ratio and platelet lymphocyte ratio showed a significant positive correlation with systolic BP observed by Pearson’s correlation. NLR (r=0.847, p<0.001) and PLR (r=0.209, p<0.009).

Conclusions: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) can be used as reliable parameters in clinical practice and in epidemiological studies as indices of inflammation among hypertensives.


Keywords


Atherothrombosis, Hypertension, Lymphocyte, Neutrophil, Platelet

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References


Mistry HA, Parmar DM. Study of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in hypertensives and normotensives. Int J Clin Exp Physiol. 2018;5(4):196-9.

Kılıçaslan B, Dursun H, Kaymak S, Aydın M, Ekmekçi C, Susam İ, et al. The relationship between neutrophil to lymphocyte ratio and blood pressure variability in hypertensive and normotensive subjects. Turk Kardiyol Dern Ars. 2015;43(1):18-24.

Forget P, Khalifa C, Defour JP, Latinne D, Van Pel MC, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes. 2017;10(1):1-4.

Cimen T, Sunman H, Efe TH, Erat M, Şahan HF, Algül E, et al. The relationship between 24-hour ambulatory blood pressure load and neutrophil-to-lymphocyte ratio. Revista Portuguesa de Cardiologia. 2017;36(2):97-105.

Liu X, Zhang Q, Wu H, Du H, Liu L, Shi H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension. Am J Hypertens. 2015;28(11):1339-46.

Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil lymphocyte ratio and cardiovascular disease risk: a systematic review and meta-analysis. BioMed Res Int. 2018;2018.

Durmus E, Kivrak T, Gerin F, Sunbul M, Sari I, Erdogan O. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are predictors of heart failure. Arquivos Brasileiros de Cardiologia. 2015;105:606-13.

Afşin A, Asoğlu R, Kurtoğlu E, Kaya H. Neutrophil to lymphocyte ratio as a predictor of left ventricular hypertrophy in patients with newly diagnosed hypertension. J Hypertens Manag. 2019;5:042.

Yıldırım ÖT, Akşit E, Aydın F, Aydın AH, Dağtekin E. Can neutrophil to lymphocyte ratio and platelet to lymphocyte ratio be used as biomarkers for non-dipper blood pressure. J Surg Med. 2018;3(1):4-7.

Karagoz A, Vural A, Gunaydin ZY, Bektas O, Gul M, Celik A, et al. The role of neutrophil to lymphocyte ratio as a predictor of diastolic dysfunction in hypertensive patients. Eur Rev Med Pharmacol Sci. 2015;19(3):433-40.

Balta S, Ozturk C, Yildirim AO, Aparci M, Demir M, Celik T. The relation between neutrophil-lymphocyte ratio and hypertension. Am J Hypertens. 2015;28(11):1386.

Yildirim OT, Aydin F, Aydin AH, Dagtekin E, Aksit E, Hasirci SH. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are independent predictors for blood pressure variability. J Hypertens. 2018;36:e12.