Published: 2022-01-29

Nanoparticles: tech trends in healthcare

Anu Chandran, Varun Raghavan, Bhaskaran Chalil, Kamalasanan ., C. C. Velayudhan, Mirvaz Zulfiker, Midhun M., Sanju Rajappan, Sily Sreedharan, Deeshma ., Remash K., Kanniyan Binub


Nanotechnology is the use of matter on an atomic, molecular, and supramolecular scale for various purposes. Nanotechnology field of application is very much diverse which includes surface science, organic chemistry, molecular biology, semiconductor physics, energy storage, engineering, microfabrication, and molecular engineering. Its medical application ranges from biological devices, nano-electronic biosensors, and to future biological machines. The main issue nowadays for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. Lot more functionalities can be added to nanomaterials by interfacing them with biological structures. The size of nanomaterials is similar most biological molecules and so useful for both in vivo and in vitro biomedical research and applications. The integration of nanomaterials with biology had paved path to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications and drug delivery vehicles.


Nanoparticle, Cancer, Chemotherapy

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Murthy SK. Nanoparticles in modern medicine: state of the art and future challenges. Int J Nanomedicine. 2007;2(2):129-41.

Zylberberg C, Matosevic S. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Drug Deliv. 2016;23(9):3319-29.

Acharya S, Sahoo SK. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Adv Drug Deliv Rev. 2011;63(3):170-83.

Luo E, Song G, Li Y, Shi P, Hu J, Lin Y. The toxicity and pharmacokinetics of carbon nanotubes as an effective drug carrier. Curr Drug Metab. 2013;14(8):879-90.

Mandriota G, Corato R, Benedetti M, Castro F, Fanizzi FP, Rinaldi R. Design and Application of Cisplatin-Loaded Magnetic Nanoparticle Clusters for Smart Chemotherapy. ACS Appl Mater Interfaces. 2019;11(2):1864-75.

Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3(1):16-20.

Choi KY, Correa S, Min J, Li J, Roy S, Laccetti KH, et al. Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles. Adv Funct Mater. 2019;29(20):1900018.

Zhu FD, Hu YJ, Yu L, Zhou XG, Wu JM, Tang Y, et al. Nanoparticles: A Hope for the Treatment of Inflammation in CNS. Front Pharmacol. 2021;12:683935.

Springer. Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy, 2021. Available at: Accessed on 18 December 2021.

Estabragh MAR, Hamidifar Z, Pardakhty A. Formulation of Rivastigmine Niosomes for Alzheimer Disease. Int Pharmacy Acta. 2018;1(1):101-4.

Kang YS, Jung HJ, Oh JS, Song DY. Use of PEGylated Immunoliposomes to Deliver Dopamine Across the Blood-Brain Barrier in a Rat Model of Parkinson's Disease. CNS Neurosci Ther. 2016;22(10):817-23.

The Michael J Foundation. Cerium Oxide Nanoparticles in Treatment of Parkinson’s Disease, 2021. Available at: Accessed on 18 December 2021.

Chountoulesi M, Demetzos C. Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System. Brain Sci. 2020;10(6):338.