DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20220521

Fate of indeterminate microbial keratitis

Shikha Jain, Ashok Pathak, Anwara Mammel, Shalini Malhotra

Abstract


Background: Previous published literature has shown that there is no significant difference between outcomes of culture positive and culture negative infective keratitis. This study was done to find the outcome in cases of indeterminate keratitis in our institute. Purpose was to highlight the fate of indeterminate microbial keratitis.

Methods: Patients presenting to cornea services of ABVIMS and Dr. RML hospital from February 2017 to April 2021 were evaluated for demographic and microbiological assessment, clinical presentation and management.

Results: The 188 out of 310 cases were microbiologically positive. No organism could be detected in 122 cases. Clinical prognosis is worse in cases of indeterminate keratitis.

Conclusions: Cases with indeterminate microbial keratitis do not show timely and appropriate response which leads to spread of infection resulting in more complications and less CDVA.


Keywords


Microbial keratitis, Indeterminate, Fate

Full Text:

PDF

References


Duarte MCB, Becker GN, Muller GG, Tuon FF. Infectious keratitis in southern Brazil: a comparison culture negative and culture positive patients. Revista Brasileira de Oftalmologia. 2020;79(1):46-52.

Bhadange Y, Das S, Kasav MK, Sahu SK, Sharma S. Comparison of culture-negative and culture-positive microbial keratitis: cause of culture negativity, clinical features and final outcome. Br J Ophthalmol. 2015;99(11):1498-502.

Keay L, Edwards K, Naduvilath T. Microbial keratitis: predisposing factors and morbidity. Ophthalmology. 2006;113:109-16.

O'Brien TP, Green WR. Keratitis. In: Mandell GL. Principles and Practice of Infectious Diseases, Chap 93, 4th ed. Churchill Livingstone: New York. 1995;1110-8.

Tewari A, Sood N, Vegad MM, Mehta DC. Epidemiological and microbiological profile of infective keratitis in Ahmedabad. Indian J Ophthalmol. 2012;60:267-72.

Katara RS, Patel ND, Sinha M. A Clinical Microbiological Study of Corneal Ulcer Patients at Western Gujarat, India. Acta Med Iran. 2013;51:399-403.

Leck AK, Thomas PA, Hagan M, Kaliamurthy J, Ackuaku E, John M, et al. Aetiology of suppurative corneal ulcers in Ghana and south India and epidemiology of fungal keratitis. Br J Ophthalmol. 2002;86:1211-5.

Alexandrakis G, Haimovici R, Miller D, Alfonso EC. Corneal biopsy in the management of progressive microbial keratitis. Am J Ophthalmol. 2000;129(5);571-6.

Schaefer F, Bruttin O, Zagrafos L, Guex-Corsier Y. Bacterial keratitis: a prospective clinical and microbiological Study. Br J Ophthalmol. 2001;85:842-7.

Bernet HA, Hay J, Kirkness CM. Antimicrobial management of presumed microbial keratitis: Guidelines for treatment for central and peripheral ulcers. Br J Ophthalmol. 1998;82:137-45.

Vajpayee RB, Dada T, Saxena R, Vajpayee M, Taylor HR, Venkatesh P et al. Study of the first Contact management profile of cases of infective keratitis: a hospital-based study. Cornea. 2000;19:52-6.

Bourcier T, Thomas F, Borderie V, Chaumeil C, Laroche L. Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br J Ophthalmol. 2003;87(7):834-8.

Oliveira-Ferreira C, Leuzinger-Dias M, Tavares-Ferreira J, Torrão L, Falcão-Reis F. Microbiological Profile of Infectious Keratitis in a Portuguese Tertiary Centre. J Ophthalmol. 2019;2019:6328058.

Moxon R, Rappuoli R. Bacterial pathogen genomics and vaccines. Br Med Bull. 2002;62(1):45-58.