Glial heterotopia in head and neck, single center experience of 5 cases
DOI:
https://doi.org/10.18203/2320-6012.ijrms20161994Keywords:
Glial heterotopia, Nasal cavity, Middle ear, Head and neckAbstract
Background: Heterotopic neuroglial tissue is defined as a mass composed of mature brain tissue isolated from the cranial cavity or spinal canal. The nose and the naso-pharynx are the most common sites of location. Heterotopic masses of neuroglial tissue involving non-midline structures, specifically the middle ear region, are exceptional. In this study, we present four cases of Nasal Glial Heterotopia and a single case of glial heterotopia of the middle ear from the institute. Aim and objective of the study was to study clinicopathological aspects of four cases of nasal glial heterotopia and a rare case of glial heterotopia involving the middle ear.
Methods: Neuroglial heterotopias in the head and neck region between 2008 and 2016 were evaluated. Clinical and radiological findings of these cases were analysed. Histopathological examination was the mainstay of diagnosis and Immuno-expression of glial fibrillary acid protein was done for confirmation in few cases.
Results: Five cases of glial heterotopias of head and neck were diagnosed during the study period. 4 cases of glial heterotopia of the nasal cavity and one case of glial heterotopia involving the right middle ear, was present in this study.
Conclusions: Glial Heterotopias of head and neck are more common in the nasal cavity. Middle ear Glial heterotopias are very rare. Clinical and radiological findings along with histopathology and immuno-histochemistry are essential in diagnosing these lesions.
Metrics
References
Gyure KA, Thompson LDR, Morrison AL. A Clinicopathological Study of 15 Patients with neuroglial heterotopias and encephaloceles of the Middle Ear and Mastoid Region. Laryngoscope. 2000;110:1731-5.
Dadaci M, Bayram FC, Ince B, Bilgen F. Glial heterotopia of the lip: A rare presentation. Indian J Plast Surg. 2016;49:112-5.
Farneti P, Balbi M, Foschini MP. Neuroglial choristoma of the middle ear. ACTA oto rhinolaryngologica italic. 2007;27:94-7.
Mahalik SK, Lyngdoh TS, Menon P, Sodhi KS, Vashishta RK, Kanojia RP, et al. Glial heterotopia of maxilla: A clinical surprise. J Indian Assoc Pediatr Surg. 2011;16:58-60.
Kallman JE, Loevner LA, Yousem DM, Chalian AA, Lanza DC, Li Jin, et al. Heterotopic brain in the Pterygopalatine fossa. Am J Neuroradiol. 1997;18:176-9.
Surda P, Hobson J. A Rare Case of Nasal Glial Heterotopia Presenting as Sphenochoanal Polyp. International Journal of Otolaryngology and Head and Neck Surgery. 2015;04(2). Article ID:54342,3 pages.
Hagiwara A, Nagai N, Ogawa Y, Suzuki M. A Case of Nasal Glial Heterotopia in an Adult. Case Reports in Otolaryngology. Volume 2014, Article ID 354672, 4 pages.
Penner CR, DDS, Thompson LRD. Nasal Glial Heterotopia: A Clinicopathologic and Immuno phenotypic Analysis of 10 Cases With a Review of the Literature. Annals of Diagnostic Pathology. 2003;7(6):354-9.
Altissimi G, Ascani S, Falcetti S, Cazzato C, Acta Bravi I. Central nervous system tissue heterotopias of the nose:case report and review of literature.” Acta Otorhinolaryngologica Italica. 2009;29(4):218-21.
Uz MZU, Lu SA, Terzi S, Etit D. Glial heterotopia of the middle ear.The Journal of Laryngology and Otology. 2006; E4:1 of 2.
Mahalik SK, Lyngdoh TS, Menon P, Sodhi KS, Vashishta RK, Kanojia RP, et al. Glial heterotopia of maxilla: A clinical surprise. J Indian Assoc Pediatr Surg. 2011;16:58-60.
Guez JJP, Bernabeu-Wittel J. Nasal Glial Heterotopia (Nasal Glioma) J Pediatr. 2010;156:688.
Xian J, Austin J. Computed Tomographic and Magnetic Resonance Imaging Findings in the Midline Nasopharyngeal Glial Heterotopia. Radiol. 2015;2(2):1015.
Plontke SKR, Preyer S, Pressler H, Mundinger PM, Plinkert PK. Glial lesion of the infratemporal fossa presenting as a soft tissue middle ear mass -rudimentary encephalocele or neural crest remnant?. International journal of pediatric otorhinolaryngology. 2000; 56:141-7.
Ramadass T, Narayanan N, Rao P, Parameswaran A. Glial Heterotopia in ENT-Two Case Reports and Review of Literature. Indian J Otolaryngol Head Neck Surg. 2011:63(4):407-10.
Downloads
Published
How to Cite
Issue
Section
