Real-world experience of metformin 1000 mg/day in patients with type 2 diabetes mellitus and comorbidities from Myanmar

Soe Yarzar; Myo Lin Aung; Thet Kyaw Soe; Aung Ko Ko Win; Thuzar Lwan Thar; Santosh Revankar; Tripti Sharmaa

doi:10.18203/2320-6012.ijrms20220978

Authors

Soe Yarzar M.B.B.S (Ygn), M. Med. Sc (Internal Medicine), M.R.C.P (UK), Yangon, Yangon Division, Myanmar
Myo Lin Aung Medical Department, M.B.B.S (Ygn), M.R.C.P (UK), M. Med. Sc (Int Med), Hin-Tha-Da, Ayeyarwaddy Division, Myanmar
Thet Kyaw Soe General Practitioner, M.B.B.S (Mgy) Mawlamyine, Mon State, Myanmar
Aung Ko Ko Win General Practitioner, M.B.B.S (Mdy), Diploma in Dermatology & Dermatosurgery (BKK), Mawlamyin, Mon State, Myanmar
Thuzar Lwan Thar Medical Department, M.B.B.S (Ygn), M.R.C.P (UK), M. Med. Sc (Int Med), Hin-Tha-Da, Ayeyarwaddy Division, Myanmar
Santosh Revankar Scientific Services, USV Private Limited, Mumbai, India
Tripti Sharmaa Scientific Services, USV Private Limited, Mumbai, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20220978

Keywords:

Metformin, Large dose, Random blood sugar, Hypertension, Gastrointestinal

Abstract

Background: The study was conducted to assess the efficacy and safety of 1000 (mg/day) metformin in patients with type 2 diabetes (T2DM) with comorbidities and special reference to elderly people in Myanmar.

Methods: This was a retrospective, post surveillance study conducted in patients diagnosed with T2DM receiving treatment of metformin (1000 mg/day). Baseline characteristics, comorbidities, random blood sugar level (RBS) and RBS changes pre- and post-therapy were retrieved from patient’s medical records. A paired sample t-test was used for comparing the pre- and post-treatment RBS levels.

Results: A total of 303 patients with T2DM were included. A total of 88, 115 and 100 patients belonged to age groups ≤50, >50-≤60 and >61 years, respectively. Duration of T2DM was significantly higher in elderly patients (>61 years) compared to ≤50 and >50-≤60 age group. Hypertension was the most common comorbid condition observed in all age groups followed by cardiovascular disease. However, both hypertension and cardiovascular disease were significantly higher among elderly patients (>61 years) compared to ≤50 and >50-≤60 age group (p<0.001). The mean RBS was significantly reduced at 3 months with metformin treatment in all age groups. However, mean change from baseline was comparatively higher in elderly patients with diabetes (≤50 years, 94.6 mg/dL; >50-≤60 years, 86.2 mg/dL and >61 years, 97.2 mg/dL). Metformin was well tolerated with minimal gastrointestinal adverse events (n=27).

Conclusions: In this post marketing surveillance study, metformin (1000 mg/day) was found to be effective in reducing RBS in T2DM patients with comorbidities especially older adults and well tolerated with no risk of hypoglycemia.

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