Published: 2017-01-03

Paraquat poisoning-a dreadful and lethal poisoning: a case report of two cases from East Godavari, Andhra Pradesh, India

K. Venkatanand, Aakash Agrawal, M. B. R. Sarma


Paraquat, a bipyridyl compound is used as a contact herbicide. It is a highly lethal compound with high mortality rates in cases of intentional ingestion for suicidal purpose. Although widely used in East Godavari District of Andhra Pradesh, India, cases of poisoning with this herbicide have been rarely reported from this region. This compound affects the lungs (leading to pulmonary fibrosis) and the kidney (leading to Acute Kidney Injury) the most. Ingestion of small quantities can cause death and lack of a specific antidote and specific treatment guidelines makes it a dreadful and lethal poison. We report two cases of suicidal ingestion of Paraquat which presented to the emergency department of KIMS and RF hospital, Amalapuram, East Godavari District, Andhra Pradesh, India.


Paraquat, Poisoning, Lethal, East Godavari district

Full Text:



Roberts DM. Bipyridyl Compounds, Paraquat, and Diquat in Goldfrank’s Toxicologic Emergencies, Lewis S. Nelson, Neal A. Lewin, Mary Ann Howland, Robert S. eds, McGraw Hill, NewYork, NY, USA. 2011;1502.

Geller RJ. Paraquat, Diquat in Poisoning and Drug Overdose. Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, eds, 6th edition, McGraw Hill, New York, NY, USA. 2012;321-3.

Kang MS, Gil HW, Yang JO, Lee EY, Hong SY. Comparison between kidney and hemoperfusion for paraquat elimination. J Korean Med Sci. 2009;24:S156-60.

Costa LG. Toxic Effects of Pesticides in Casarett and Doull’s Toxicology- The Basic Science of Poisons, Curtis D. Klaassen, ed 8th Edition, McGraw Hill, NewYork, NY, USA, 2013;961.

Pillay VV. “Pesticides” in Modern Medical Toxicology, V V Pillay,ed, 4th Edition, Jaypee Brothers, New Delhi, India. 2013;398-400.

Agarwal R, Srinivas R, Aggarwal AN, Gupta D. Immunosuppressive therapy in lung injury due to paraquat poisoning: a metaanalysis. Singapore Med J. 2007;48(11):1000-5.

Vale JA, Meredith TJ, Buckley BM. Paraquat poisoning: Clinical features and immediate general management. Hum Toxicol. 1987;6:41-7.

Khosya S, Gothwal S. Two Cases of Paraquat Poisoning from Kota, Rajasthan, India. Case Rep Crit Care. 2012.

Cappelletti G, Maggioni MG, Maci R. Apoptosis in human lung epithelial cells: triggering by paraquat and modulation by antioxidants. Cell Biol Int. 1998;22:671-8.

Yeh ST, Guo HR, Su YS, Lin HJ, Hou CC, Chen HM, et al. Protective effects of Nacetylcysteine treatment post-acute paraquat intoxication in rats and in human lung epithelial cells. Toxicology. 2006;223:181-90.

Wong OF, Fung HT, Kam CW. Case series of paraquat poisoning in Tuen Mun Hospital. Hong Kong J Emerg Med. 2006;13:155-60.

Pavan M. Acute kidney injury following Paraquat poisoning in India, Iran J Kidney Dis. 2013;7(1):64-6.