Effects of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, right ovary and liver in female rats

Authors

  • Barinua K. Gbaranor Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Onisojime M. Alasia Department of Pharmacology, College of Medical Sciences, Niger Delta University, Bayelsa, Nigeria, India
  • Popnen G. Tee Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Tamunobarabiye I. Nonju Department of Pharmacology and Therapeutics Pharmacology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Iyingiala Austin-Asomeji Department of Community Medicine, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Imaobong I. Nonju Department of Human Physiology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Ihundah Nmehielle Department of Pharmacology and Therapeutics Pharmacology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Adetomi Bademosi Department of Community Medicine, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Sarah K. Enebeli Department of Pharmacology and Therapeutics Pharmacology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Ucheawaji F. Edward Department of Pharmacology and Therapeutics Pharmacology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Valentime N. Nnoka Department of Pharmacology and Therapeutics Pharmacology, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Boobondah J. Woha Department of Medical Biochemistry, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20221783

Keywords:

Changes, Body weight, Right ovary, Uterus, Liver

Abstract

 

Background: Most people across rural areas in Africa depends of phytomedicine for the treatment of various diseases. This study aims to evaluate the impact of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, ovary and liver of female Wistar rats.

Methods: Forty-nine female rats were randomly selected into nine groups with five rats per group. Group 1 received 5 ml/kg of water, group 2 received mono sodium glutamate (MSG) 800 mg/kg, group 3 received extract 100 mg/kg, group 4 received extract 200 mg/kg, group 5 received extract 400 mg/kg, group 6 received extract 100 mg/kgand MSG 800 mg/kg, group 7 received extract 200 mg/kgand MSG 800vmg/kg, group 8 received extract 400 mg/kg and MSG 800 mg/kg and group 9 received letrozole 0.6 mg/kg and MSG 800 mg/kg. Administration of extract was done for 28 days.

Results: Findings from the study revealed significance decreased in the final weight of the animals. When treated groups received extract “100 mg/kg, extract 200 mg/kg, extract 400 mg/kg, and extract 200 mg/kg and MSG 800 mg/kg”, it shows significance decreased in body weight difference. The results also show significance increased in the weight of the right ovary in the treated groups extract 100 mg/kg, extract 100 mg/kg and MSG 800 mg/kg. Extract 100 mg/kg, extract 400 mg/kg and MSG 800 mg/kg and letrozole 0.6 mg/kg and MSG 800 mg/kg, shows significance decreased in the weight of the uterus. MSG 800 mg/kg, “extract 100 mg/kg, extract 200 mg/kg, and extract 400 mg/kg”, it shows significance decreased in the weight of the liver. Statistical analysis was done using statistical package for the social sciences (SPSS) version 23 and p<0.05 was significant.

Conclusions: There was significance decreased in rat’s body weight and significant increase in the right ovary when a lower dose of the extract was given and this increase could be due to MSG. The uterus significantly decreases when low dose of the extract was administered and the liver organ also has significant decreased in all the groups treated with extract alone.

References

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Published

2022-06-28

How to Cite

Gbaranor, B. K., Alasia, O. M., Tee, P. G., Nonju, T. I., Austin-Asomeji, I., Nonju, I. I., Nmehielle, I., Bademosi, A., Enebeli, S. K., Edward, U. F., Nnoka, V. N., & Woha, B. J. (2022). Effects of hydro-alcohol extract of mistletoe leaves on changes in body-weight, uterus-weight, right ovary and liver in female rats. International Journal of Research in Medical Sciences, 10(7), 1421–1425. https://doi.org/10.18203/2320-6012.ijrms20221783

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Original Research Articles