Clobetasol propionate cream 0.025%: a topical therapeutic for dermatological disorders


  • Gnansekaran R. Department of Dermatology, Kaya Clinic, Madurai, Tamil Nadu, India
  • Chand Mohammad Department of Dermatology, Domkal Super speciality Hospital, Baharampur, West Bengal, India
  • Nirmal Kumar Saini Department of Dermatology, Skin Care Clinic, Sri Ganganagar, Rajasthan, India
  • Vivek Aggarwal Department of Dermatology, Vivek Skin Care Clinic, Kurukshetra, Haryana, India
  • Sameer Mishra Department of Dermatology, Berkowits Hair And Skin Clinic, New Delhi, India
  • Surjit Singh Mehta Department of Dermatology, Fortis Hospital, Delhi, India
  • Bhabhor Rahul Satvantsinh Department of Dermatology, Divyanshi Skin & Cosmetic Clinic, Dahod, Gujarat, India
  • Mure Sri Hari Prasanna Department of Dermatology, Sri Haari Skin Hospital, Rajahmundry, Andhra Pradesh, India
  • Satu Srikanth Department of Dermatology, Aadhya Skin Hair & Laser Clinic, Warangal, Telangana
  • Alka Gupta Department of Dermatology, Gupta Clinic, Janakpuri, New Delhi, India



Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids


Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is the most popular topical medication used to treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, and immunosuppressive characteristics. The USFDA has approved CP 0.025% cream for the treatment of moderate-to-severe psoriasis in adults. Propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers are all recognized contact allergens, and the formulation has exhibited hypoallergenic effects. CP 0.025% is an effective and safe agent due to its high active ingredient penetration and minimal systemic absorption. The clinical experience of employing CP 0.025% cream in diverse dermatologic disorders is discussed in this case series, with a focus on its efficacy and safety.


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How to Cite

R., G., Mohammad, C., Saini, N. K., Aggarwal, V., Mishra, S., Mehta, S. S., Satvantsinh, B. R., Prasanna, M. S. H., Srikanth, S., & Gupta, A. (2022). Clobetasol propionate cream 0.025%: a topical therapeutic for dermatological disorders. International Journal of Research in Medical Sciences, 10(5), 1169–1175.



Case Series