Clobetasol propionate cream 0.025%: a topical therapeutic for dermatological disorders

Gnansekaran R., Chand Mohammad, Nirmal Kumar Saini, Vivek Aggarwal, Sameer Mishra, Surjit Singh Mehta, Bhabhor Rahul Satvantsinh, Mure Sri Hari Prasanna, Satu Srikanth, Alka Gupta


Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is the most popular topical medication used to treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, and immunosuppressive characteristics. The USFDA has approved CP 0.025% cream for the treatment of moderate-to-severe psoriasis in adults. Propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers are all recognized contact allergens, and the formulation has exhibited hypoallergenic effects. CP 0.025% is an effective and safe agent due to its high active ingredient penetration and minimal systemic absorption. The clinical experience of employing CP 0.025% cream in diverse dermatologic disorders is discussed in this case series, with a focus on its efficacy and safety.


Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids

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Siegfried EC, Hebert AA. Diagnosis of Atopic Dermatitis: Mimics, Overlaps, and Complications. J Clin Med. 2015;4(5):884-917.

Rosso JQ. Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. J Clin Aesthet Dermatol. 2020;13(2):22-9.

Gabros S, Nessel TA, Zito PM. Topical Corticosteroids. StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.

Draelos ZD, Fowler JF, Cornelison R. A randomized, parallel group, open label, multicenter study to assess the potential for adrenal suppression and systemic drug absorption following multiple dosing with clobetasol propionate cream (Impoyz™), 0.025% versus clobetasol propionate (Temovate®). Skin JCMS. 2018;2(6).

Dopytalska K, Sobolewski P, Błaszczak A. Psoriasis in special localizations. Reumatologia. 2018;56(6):392.

Singh JK, Zanwar YR, Kumar J. Role of topical corticosteroid therapy in various dermatoses. Int J Res Med Sci 2021;9:34-41.

USFDA. Impoyz (Clobetasol propionate Cream, 0.025%), 2017. Available at: https://www.access Accessed on 4th March 2022.