Clobetasol propionate cream 0.025%: a topical therapeutic for dermatological disorders

Gnansekaran R.; Chand Mohammad; Nirmal Kumar Saini; Vivek Aggarwal; Sameer Mishra; Surjit Singh Mehta; Bhabhor Rahul Satvantsinh; Mure Sri Hari Prasanna; Satu Srikanth; Alka Gupta

doi:10.18203/2320-6012.ijrms20221021

Authors

Gnansekaran R. Department of Dermatology, Kaya Clinic, Madurai, Tamil Nadu, India
Chand Mohammad Department of Dermatology, Domkal Super speciality Hospital, Baharampur, West Bengal, India
Nirmal Kumar Saini Department of Dermatology, Skin Care Clinic, Sri Ganganagar, Rajasthan, India
Vivek Aggarwal Department of Dermatology, Vivek Skin Care Clinic, Kurukshetra, Haryana, India
Sameer Mishra Department of Dermatology, Berkowits Hair And Skin Clinic, New Delhi, India
Surjit Singh Mehta Department of Dermatology, Fortis Hospital, Delhi, India
Bhabhor Rahul Satvantsinh Department of Dermatology, Divyanshi Skin & Cosmetic Clinic, Dahod, Gujarat, India
Mure Sri Hari Prasanna Department of Dermatology, Sri Haari Skin Hospital, Rajahmundry, Andhra Pradesh, India
Satu Srikanth Department of Dermatology, Aadhya Skin Hair & Laser Clinic, Warangal, Telangana
Alka Gupta Department of Dermatology, Gupta Clinic, Janakpuri, New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20221021

Keywords:

Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids

Abstract

Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is the most popular topical medication used to treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, and immunosuppressive characteristics. The USFDA has approved CP 0.025% cream for the treatment of moderate-to-severe psoriasis in adults. Propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers are all recognized contact allergens, and the formulation has exhibited hypoallergenic effects. CP 0.025% is an effective and safe agent due to its high active ingredient penetration and minimal systemic absorption. The clinical experience of employing CP 0.025% cream in diverse dermatologic disorders is discussed in this case series, with a focus on its efficacy and safety.

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