Published: 2022-06-28

Increased mean platelet volume is associated with acute myocardial infarction in patients with diabetes mellitus type 2

Emina Dervisevic, Anes Jogunčić, Muamer Dervišević, Adis Salihbegović, Haris Vukas, Samra Kadić-Vukas, Subhija Prasko, Ferid Krupić


Background: The correlation between diabetes mellitus and acute myocardial infarction is greater every day. The mean platelet volume (MPV), which is the determinant of platelet function, is an independent risk factor for the cardiovascular disease. The aim of the study was to investigate the effect of each disease (hypothyroidism, hypertension, myocardial infarction) individually and combined on MPV in diabetic patients.

Methods: The cross-sectional study included 102 patients who suffer from diabetes mellitus type 2 (DMT2), of both sexes (46 females, 56 males), with the average age of 58.91 (SD=12.93). All the patients were treated at the Primary Health Centre in Zenica from May to July 2017. All patients had diabetes mellitus and the disease had lasted for 10 years in both sexes.

Results: Mean platelet volume was significantly higher in patients with myocardial infarction than in those without myocardial infarction. Age, sex, HbA1c, BMI, lipids and platelet count did not show any significance in either group of patients. Regression analysis showed that the prevalence of myocardial infarction had the highest predictive significance for MPV values, (predictor importance 0.49; coefficient 1.275, p<0.001).

Conclusions: Mean platelet volume was significantly higher in patients with diabetes mellitus and myocardial infarction than in DM patients without myocardial infarction. Regression analysis showed correlation with acute myocardial infarction in patients with DMT2, but not with other chronic illnesses. The highest platelet volume indices were observed in patients with myocardial infarction. MPV can be used as a specific indicator in diabetic patients with myocardial infarction.  



Diabetes mellitus, Mean platelet volume, Myocardial infarction, Thyroid disease

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Kubisz P, Stančiaková L, Staško J, Galajda P, Mokáň M. Endothelial and platelet markers in diabetes mellitus type 2. World J Diabetes. 2015;6:423-31.

Michelson AD. Methods for the measurement of platelet function. Am J Cardiol. 2009;103:20-6

Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010;8:148-56.

Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2004;15:475-8.

Demirtas L, Degirmenci H, Akbas EM, Ozcicek A, Timuroglu A. Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med. 2015;8:11420-7.

Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17(1):47-58.

Türkoğlu A, Gül M, Oğuz A, Bozdağ Z, Ülger B. Mean Platelet Volume: Is It a Predictive Parameter in Diagnosis of Acute Mesenteric Ischemia? International Surgery. 2015;100(5):962-5.

Erikci AA, Karagoz B, Ozturk A, Caglayan S, Ozisik G. The effect of subclinical hypothyroidism on platelet parameters. Hematology. 2009;14:115-7.

Coban E, Yazicioglu G, Ozdogan M. Platelet activation in subjects with subclinical hypothyroidism. Med Sci Monit. 2007;13:CR211-4.

Yilmaz H, Ertugrul O, Ertugrul B, Ertuğrul D. Mean platelet volume in patients with subclinical hypothyroidism. Platelets. 2011;22:143-7.

Kim JH, Park JH, Kim SY, Bae HY. The mean platelet volume is positively correlated with serum thyrotropin concentrations in a population of healthy subjects and subjects with unsuspected subclinical hypothyroidism. Thyroid. 2013;23:31-7.

Ren X, Meng Z, Liu M, Zhu M, Qing He. No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese. Fröhlich. E, ed. Medicine. 2016;95(40):4573.

Pusuroglu H, Cakmak HA, Erturk M, Akgul B, Akkaya E. Assessment of the Relation between Mean Platelet Volume, Non-Dipping Blood Pressure Pattern, and Left Ventricular Mass Index in Sustained Hypertension. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 2014;20:2020-6.

Ferreiro JL, Gómez-Hospital JA, Angiolillo DJ. Platelet abnormalities in diabetes mellitus. Diab Vasc Dis Res. 2010;7:251-9.

Schneider DJ. Factors contributing to increased platelet reactivity in people with diabetes. Diabetes Care. 2009;32:525-7.

Kakouros N, Rade JJ, Kourliouros A, Resar JR. Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective. Int J Endocrinol. 2011;2011:742719.

Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL. Platelet dysfunction in type 2 diabetes. Diabetes Care 2001;24:1476-85.

Sewell R, Ibbotson RM, Phillps R. High mean platelet volume after myocardial infarction: is it due to consumption of small platelets? Br Med J. 1984;289:1576-8.

Gibson CM, Murphy SA, Rizzo MJ, Ryan KA, Marble SJ. Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) Study Group. Circulation. 1999;99:1945-50.

Boos CJ, Balakrishnan B, Lip GY. The effects of coronary artery disease severity on time-dependent changes in platelet activation indices in stored whole blood. J Thromb Thrombolysis. 2008;25:135-40.

Yilmaz MB, Cihan G, Guray U, Kisacik HL, Sasmaz H. Role of mean platelet volume in triagging acute coronarysyndromes. J Thromb Thrombolysis. 2008;26:49-54.

Ren X1, Meng Z, Liu M, Zhu M, He Q. No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese. Medicine (Baltimore). 2016;95(40):e4573.

Varol E, Icli A, Ozaydin M, Erdogan D, Arslan A. Mean platelet volume is elevated in patients with myocardial infarction with normal coronary arteries, as in patients with myocardial infarction with obstructive coronary artery disease. Scand J Clin Lab Invest. 2009;69(5):570-4.