Published: 2017-01-04

Breast cancer survival studies in India: a review

Jignasa Sathwara, Saurabh Bobdey, Ganesh B.


Length of survival of cancer patients is an important indicator for knowing the outcome of treatment in any study. Epidemiological features and biological profile of breast cancer appear to be different in developing countries as compared to Western countries. Knowing the factors that influence survival rates among women with breast cancer may help define early detection actions, and improve treatment and care proposals in all the areas of health. Therefore, this study aims to identify, the publications defining the factors influencing survival for women with breast cancer in India. PUBMED database was searched from January 1990 to April 2016, using the key words Breast cancer, breast cancer outcome and Survival and their corresponding Mesh terms were used in combination with Boolean operators like OR, AND. Five year overall survival rate of breast cancer in India ranged from 40-62%. The results from 16 publications showed that survival of breast cancer varies widely depending on number of factors like age, stage at diagnosis, marital status, educational level, hormonal status, clinical extent of disease and treatment. The publications that make up this review present contributing factors that affect the survival rate of women with breast cancer in India. This information on survival studies can pinpoint the lacunae in treatment modalities and can guide us to do basic and translational research so the preventive strategies can be implemented.


Survival rate, Breast cancer, India

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Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9-29.

Singhai R, Patil V W, Patil A V. Status of HER-2/neu receptors and Ki-67 in breast cancer of Indian women. Int J App Basic Med Res. 2011;1:15-9.

Murthy NS, Chaudhry K, Nadayil D, Agarwal UK, Saxena S. Changing trends in incidence of breast cancer: Indian scenario. Indian J Cancer. 2009;46(1):73-4.

Coughlin SS, Cypel Y. Epidemiology of Breast Cancer in Women. Breast cancer Metastasis and drug resistance Progress and prospects, 2013, XII, 416. 978-1-4614-5646-9

McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ. 2000;321(7261):624-8.

Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev. 1993;15(1):36-47.

Weigelt B, Peterse JL, van 't Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer. 2005;5(8):591-602.

Martins da RL, Vera R. Survival rates to woman with breast cancer: review. Texto contexto - enferm. [Internet]. 2012. [cited 2015 Sep 09];

Ganesh B, Talole SD, Dikshit R, Badwe RA, Dinshaw KA. Estimation of survival rates of breast cancer patients a hospital-based study from Mumbai. Asian Pac J Cancer Prev. 2008;9(1):53-7.

Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2015;385:977-1010.

Yeole BB, Kurkure AP, Sunny L. Cancer survival in Mumbai (Bombay), India, 1992-1999. IARC Sci Publ. 2011;(162):133-42.

Jayalekshmi P, Gangadharan P, Sebastian P. Cancer survival in Karunagappally, India, 1991-1997. IARC Sci Publ. 2011;(162):125-32.

Jayant K, Nene BM, Dinshaw KA, Badwe RA, Panse NS, Thorat RV. Cancer survival in Barshi, India, 1993-2000. IARC Sci Publ. 2011;(162):101-6.

Swaminathan R, Rama R, Nalini S, Shanta V. Cancer survival in Chennai (Madras), India, 1990-1999. IARC Sci Publ. 2011;(162):115-24.

Dikshit R, Kanhere S, Surange S. Cancer survival in Bhopal, India, 1991-1995. IARC Sci Publ. 2011;(162):107-13.

Leong SP, Shen ZZ, Liu TJ, Agarwal G, Tajima T, Paik NS, et al. Is breast cancer the same disease in Asian and Western countries? World J Surg; 34:2308-24.

Chopra R. The Indian scene. J Clin Oncol. 2001;19:106S-11S.

Ali R, Mathew A, Rajan B. Effects of socio-economic and demographic factors in delayed reporting and late-stage presentation among patients with breast cancer in a major cancer hospital in South India. Asian Pac J Cancer Prev. 2008; 9:703-7.

Adami HO, Malker B, Holmberg L, Persson I, Stone B. The relation between survival and age at diagnosis in breast cancer. N Engl J Med. 1986;315:559-63.

Ganesh B, Talole SD, Dikshit R, Badwe RA, Dinshaw KA. Estimation of survival rates of breast cancer patients--a hospital-based study from Mumbai. Asian Pac J Cancer Prev. 2008;9(1):53-7.

Nandakumar A, Anantha N, Venugopal TC, Sankaranarayanan R, Thimmasetty K, Dhar M. Survival in breast cancer: a population-based study in Bangalore, India. Int J Cancer. 1995;60(5):593-6.

Yeole BB, Kumar AV, Kurkure A, Sunny L. Population-based survival from cancers of breast, cervix and ovary in women in Mumbai, India. Asian Pac J Cancer Prev. 2004;5(3):308-15.

Gajalakshmi CK, Shanta V, Swaminathan R, Sankaranarayanan R, Black RJ. A population-based survival study on female breast cancer in Madras, India. Br J Cancer. 1997;75(5):771-5.

Bonnier P, Romain S, Charpin C, Lejeune C, Tubiana N, Martin PM, et al. Age as a prognostic factor in breast-cancer: Relationship to pathological and biologic features. Int J Cancer. 1995;62:138-44.

Xiong QH, Valero V, Kau V, Kau SW, Taylor S, Smith TL, et al. Female patients with breast carcinoma age 30 years and younger have a poor prognosis: The M.D. Anderson Cancer Center Experience. Cancer. 2001;92:2523-8.

Kollias J, Elston CW, Ellis IO, Robertson JF, Blamey RW. Early-onset breast cancer-histopathological and prognostic considerations. Br J Cancer. 1997;75:1318-23.

Yildirim E, Dalgic T, Berberoglu U. Prognostic significance of young age in breast cancer. J Surg Oncol. 2000;74:267-72.

Winchester DP, Osteen RT, Menck HR. The National cancer data base report on breast carcinoma characteristics and outcome in relation to age. Cancer. 1996;78:1838-43.

Colleoni M, Rotmensz N, Robertson C, Orlando L, Viale G, Renne G, et al. Very young women (<35 years) with operable breast cancer: Features of disease at presentation. Ann Oncol. 2002;13:273-9.

Swanson GM, Lin CS. Survival patterns among younger women with breast cancer: The effects of age, race, stage, and treatment. J Natl Cancer Inst Monogr. 1994;16:69-77.

Somdatta P, Baridalyne N. Awareness of breast cancer in women of an urban resettlement colony. Indian J Cancer. 2008;45:149-53.

Mandal S, Sen A, Kar S, Roy K, Hait A. Distribution of Cancer Patients According to Time Taken From Starting Day of Symptoms to Reporting at a Regional Cancer Institute in Eastern India. Asian Pac J Cancer Prev. 2001;2:281-6.

Richards MA, Westcombe AM, Love SB, Littlejohns P, Ramirez AJ. Influence of delay on survival in patients with breast cancer: a systematic review. Lancet. 1999;353:1119-26.

Siddiqui HA, Gupta SM, Tyagi BB, Farhat J. Estimation of Survival Rates of Female Breast Cancer Patients in Meerut City, India. American Journal of Cancer Epidemiology and Prevention 2014;1-19.

Agarwal G, Ramakant P. Breast Cancer Care in India: The Current Scenario and the Challenges for the Future. Breast Care (Basel). 2008;3(1):21-7.

Macià F, Porta M, Murta-Nascimento C, Servitja S, Guxens M, Burón A, et al. Factors affecting 5- and 10-year survival of women with breast cancer: an analysis based on a public general hospital in Barcelona. Cancer Epidemiol. 2012;36(6):554-9.

Dinshaw KA, Budrukkar AN, Chinoy RF, Sarin R, Badwe R, Hawaldar R, et al. Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2005;63(4):1132-41.

Kaul R, Sharma J, Minhas SS, Mardi K. Hormone Receptor Status of Breast Cancer in the Himalayan Region of Northern India. The Indian Journal of Surgery. 2011;73(1):9-12.

Ambroise M, Ghosh M, Mallikarjuna VS, Kurian A. Immunohistochemical profile of breast cancer patients at a tertiary care hospital in South India. Asian Pac J Cancer Prev. 2011;12:625-9.

Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF. Hormone receptor status of breast cancer in India: A study of 798 tumours. Breast. 2000;9:267-70.

Shet T, Agrawal A, Nadkarni M, Palkar M, Havaldar R, Parmar V, et al. Hormone receptors over the last 8 years in a cancer referral center in India: What was and what is? Indian J Pathol Microbiol. 2009;52:171-4.

Hortobagyi GN, de la Garza Salazar J, Pritchard K, et al. The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer. 2005;6:391-401.

Sofi GN, Sofi JN, Nadeem R, Shiekh RY, Khan FA, Sofi AA, et al. Estrogen receptor and progesterone receptor status in breast cancer in relation to age, histological grade, size of lesion and lymph node involvement. Asian Pac J Cancer Prev. 2012;13(10):5047-52.

Rampaul RS, Pinder SE, Elston CW, Ellis IO. Nottingham Breast Team. Prognostic and predictive factors in primary breast cancer and their role in patient management: The Nottingham Breast Team. Eur J Surg Oncol. 2001;27(3):229-38.

Mori I, Yang Q, Kakudo K. Predictive and prognostic markers for invasive breast cancer. Pathol Int. 2002;52:186-94.

Venkatesan P, Raman TT, Ponnuraja C. Survival analysis of women with breast cancer under adjuvant therapy in South India. Asian Pac J Cancer Prev. 2011;12(6):1533-5.

Mahmood H, Faheem M, Mahmood S, Sadiq M, Irfan J. Impact of age, tumor size, lymph node metastasis, stage, receptor status and menopausal status on overall survival of breast cancer patients in Pakistan. Asian Pac J Cancer Prev. 2015;16(3):1019-24.

Nair MK, Sankaranarayanan R, Nair KS, Amma NS, Varghese C, Padmakumari G, Cherian T. Overall survival from breast cancer in Kerala, India, in relation to menstrual, reproductive, and clinical factors. Cancer. 1993;71(5):1791-6.

Gajalakshmi CK, Shanta V, Hakama M. Survival from contralateral breast cancer. Breast Cancer Res Treat. 1999;58(2):115-22.

Raina V, Bhutani M, Bedi R, Sharma A, Deo SV, Shukla NK, Mohanti BK, Rath GK. Clinical features and prognostic factors of early breast cancer at a major cancer center in North India. Indian J Cancer. 2005;42(1):40-5.

Deo SV, Samaiya A, Shukla NK, Mohanti BK, Raina V, Purkayastha J, Bhutani M, Kar M, Hazarika S, Rath GK. Breast conservation therapy for breast cancer: patient profile and treatment outcome at a tertiary care cancer centre. Natl Med J India. 2005;18(4):178-81.

Yadav BS, Sharma SC, Singh R, Singh G, Kumar V. Postmastectomy radiation and survival in patients with breast cancer. J Cancer Res Ther. 2007;3(4):218-24.

Yadav BS, Sharma SC, Singh R, Singh G. Patterns of relapse in locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiotherapy. J Cancer Res Ther. 2007;3(2):75-80.

Shanta V, Swaminathan R, Rama R, Radhika R. Retrospective analysis of locally advanced noninflammatory breast cancer from Chennai, South India, 1990-1999. Int J Radiat Oncol Biol Phys. 2008;70(1):51-8.

Raina V, Kunjahari M, Shukla NK, Deo SV, Sharma A, Mohanti BK, Sharma DN. Outcome of combined modality treatment including neoadjuvant chemotherapy of 128 cases of locally advanced breast cancer: data from a tertiary cancer center in northern India. Indian J Cancer. 2011;48(1):80-5.

Ali Siddiqui H, Gupta SM, Tyagi BB, Farhat J. Estimation of Survival Rates of Female Breast Cancer Patients in Meerut City, India. American Journal of Cancer Epidemiology and Prevention. 2014;2:1-9.

Khadakban D, Gorasia-Khadakban T, Vijaykumar DK, Pavithran K, Anupama R. Factors associated with better survival after surgery in metastatic breast cancer patients. Indian J Surg Oncol. 2013;4(1):52-8.

Vettuparambil A, Chirukandath R, Culas TB, Vijayan SM, Rajan G, Kuttappan SV. Hormone-receptor expression and survival patterns in operated cases of female invasive ductal breast carcinoma in Kerala: a retrospective cohort study. World J Surg Oncol. 2015;13:160.