Published: 2017-01-04

Beta-2 GPI induced tissue factor and placental apoptosis for the pathophysiology of pregnancy loss in antiphospholipid syndrome

Shanmugam Velayuthaprabhu, Hidehiko Matsubayashi, Govindaraju Archunan


Based on large concurrent studies on human and in vivo results from experimental animals, it is evident that antiphospholipid syndrome (APS) plays a vital role in pregnancy failure in human being. Many underlying pathophysiology including venous thrombosis, thrombocytopenia and placental apoptosis have been demonstrated for the APS-mediated pregnancy loss. On the other hand, Tissue factor (TF) remains considered as a crucial factor for pregnancy morbidity in women with APS globally. Hence, we hypothesize that TF and/or beta-2 glycoprotein – I (β2GPI)-induced TF might play an important role for the increased index of apoptosis in placenta, especially during early stages of fetal development. Further, this could represent as potentially preventable etiology of APS-mediated pregnancy loss in women.


Antiphospholipid syndrome, Tissue factor, Placental apoptosis, Recurrent pregnancy loss

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