Beta-2 GPI induced tissue factor and placental apoptosis for the pathophysiology of pregnancy loss in antiphospholipid syndrome

Authors

  • Shanmugam Velayuthaprabhu Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, Tamilnadu
  • Hidehiko Matsubayashi Reproduction Clinic Osaka, Board Certified by Japan Society for Reproductive Medicine, Kita, Osaka 530-0011
  • Govindaraju Archunan Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, Tamilnadu

DOI:

https://doi.org/10.18203/2320-6012.ijrms20162267

Keywords:

Antiphospholipid syndrome, Tissue factor, Placental apoptosis, Recurrent pregnancy loss

Abstract

Based on large concurrent studies on human and in vivo results from experimental animals, it is evident that antiphospholipid syndrome (APS) plays a vital role in pregnancy failure in human being. Many underlying pathophysiology including venous thrombosis, thrombocytopenia and placental apoptosis have been demonstrated for the APS-mediated pregnancy loss. On the other hand, Tissue factor (TF) remains considered as a crucial factor for pregnancy morbidity in women with APS globally. Hence, we hypothesize that TF and/or beta-2 glycoprotein – I (β2GPI)-induced TF might play an important role for the increased index of apoptosis in placenta, especially during early stages of fetal development. Further, this could represent as potentially preventable etiology of APS-mediated pregnancy loss in women.

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Published

2017-01-04

How to Cite

Velayuthaprabhu, S., Matsubayashi, H., & Archunan, G. (2017). Beta-2 GPI induced tissue factor and placental apoptosis for the pathophysiology of pregnancy loss in antiphospholipid syndrome. International Journal of Research in Medical Sciences, 4(8), 3109–3113. https://doi.org/10.18203/2320-6012.ijrms20162267

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Section

Review Articles