Neutrophil to lymphocyte ratio and correlation with hepatic fibrosis in patients with chronic hepatitis B

Authors

  • Umashankar Uyigowdanahally Shivalingappa Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India
  • Akilandeshwari Alagan Ramasamy Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India
  • Kani Shaikh Muhammed Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India
  • Anand A. Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India
  • Arun N. Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20221984

Keywords:

CHB, Fibrosis, Neutrophil to lymphocyte ratio, Fibroscan

Abstract

Background: Chronic hepatitis B (CHB) is a dynamic condition involving interaction between the hepatitis B virus, hepatocyte and host immune system. Neutrophil-lymphocyte ratio (NLR) is a cheap, easily available bedside inflammatory marker. The aim of the study was to assess the role of NLR to assess the fibrosis in CHB patients 

Methods: It was a prospective cross-sectional study done between January 2021-December 2021, 61 patients with CHB of age 16-50 years were included. Basic demographic and laboratory parameter were assessed. Fibrosis was assessed using fibroscan (ECHOSENS) 502 model. Using NLR cut-off of 1.9 fibrosis was assessed in different groups.

Results:  The mean age was 34±13.1 years, 66% were male patients. The mean haemoglobin, total count, platelet counts were 11.3±2.1 g/dl, 7250±2100 cells/ml, 146000±26000/ml respectively. The 38 (62.3%) patients were HBeAg positive and 23 (37.7%) patients HBeAg negative. The 28 (45.1%) patients had no significant fibrosis (<8 kpa) and 33 (54.09%) patients had significant fibrosis (>8 kpa). The 33 patients with significant fibrosis 30 patients had NLR of less than 1.9 and 3 had NLR>1.9. The 28 patients who had fibrosis of less than 6.5 kpa, 26 had NLR more than 1.9 and 2 patients with less than 1.9. Mean N/L ratio values were notably lower in cases with advanced fibrosis when compared to individuals with no/minimal fibrosis (p<0.0001). APRI was among 0.32±0.18 and 0.86±0.21 among patients with NLR<1.9 and >1.9 respectively (p=0.0001)

Conclusions: Decreased N/L ratio is significantly associated with fibrosis severity and can be utilised to identify patients with advanced disease.

Author Biography

Anand A., Department of Digestive Health and Diseases, Kilpauk Medical College, Chennai, Tamil Nadu, India

Kilpauk Medical College

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Published

2022-07-27

How to Cite

Shivalingappa, U. U., Ramasamy, A. A., Muhammed, K. S., A., A., & N., A. (2022). Neutrophil to lymphocyte ratio and correlation with hepatic fibrosis in patients with chronic hepatitis B. International Journal of Research in Medical Sciences, 10(8), 1710–1714. https://doi.org/10.18203/2320-6012.ijrms20221984

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Original Research Articles