Primary pleural myxoid liposarcoma: case report and literature review
DOI:
https://doi.org/10.18203/2320-6012.ijrms20222282Keywords:
Pleural liposarcoma, Myxoid liposarcoma, Pleural tumorAbstract
Myxoid liposarcoma is a histological subtype of malignant tumors within the group of sarcomas. It is more common in men between the ages of 40 and 50 years. Diagnosis is difficult because they are usually asymptomatic lesions, computed tomography (CT) scan and magnetic resonance are the studies of choice. The gold of treatment is surgical resection with free margins. Chemotherapy and radiotherapy have shown a good response. A 46-year-old male was detected incidental mediastinal lesion by radiography, CT scan showed a hypodense lesion in the right hemithorax that extended to the left hemithorax, infiltrating the diaphragm and large vessels. The patient underwent an exploratory thoracotomy, finding a multilobulated tumor and mucous content approximately 600 ml, adjacent structures were infiltrated, so complete resection was not possible. Subsequently, adjuvant chemotherapy given. The histopathological diagnosis was myxoid liposarcoma. Myxoid liposarcoma is a malignant lesion. The primary pleural origin is rare. Surgical resection with free margins has a good prognosis. Due to advanced disease, a complete resection in this case was not possible, that compromised the patient prognosis.
References
Araujo-Cuauro JC, Sánchez M. Primary myxoid liposarcoma of the lung of low degree of malignancy an exceptional mesenchymal neoplasm. Venezuelan J Oncol. 2021;33(3):161-9.
Muratori F, Bettini L, Frenos F, Mondanelli N, Greto D, Livi L, et al. Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution. Int J Surg Oncol. 2018;8928706.
Caro-Sánchez CHS, Flores-Balcázar CH, Mejía-Pérez A, et al. A myxoid/round cell liposarcoma is a rare variant of soft tissue sarcoma characterized by a morphological continuum in which tumor progression goes from a low-grade myxoid lesion to a high grade tumor with round cells. The most common site of appearance. Rev Mex Mastol. 2014;4(2):52-7.
Bock S, Hoffmann DG, Jiang Y, Chen H, Il'yasova D. Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001-2016. Int J Environ Res Public Health. 2020;17(8):2710.
Lee ATJ, Thway K, Huang PH, Jones RL. Clinical and Molecular Spectrum of Liposarcoma. J Clin Oncol. 2018;36(2):151-9.
Matsukuma S, Oshika Y, Utsumi Y, Obara K, Tanimoto T, Katsurada Y, Takeo H. Pleural dedifferentiated liposarcoma: A case report. Mol Clin Oncol. 2019;10(1):132-6.
Katz D, Boonsirikamchai P, Choi H, Lazar AJ, Wang WL, Xiao L, Park MS, Ravi V, Benjamin RS, Araujo DM. Efficacy of first-line doxorubicin and ifosfamide in myxoid liposarcoma. Clin Sarcoma Res. 2012;2(1):2.
Prabhakar N, Vaiphei K, Vishwajeet V, Ramamoorthy E, Gorsi U, Dhooria S, Kapoor R, Sandhu MS. Primary pleural liposarcoma: A rare entity. Lung India. 2019;36(5):438-40.
Dürr HR, Rauh J, Baur-Melnyk A, Knösel T, Lindner L, Roeder F, Jansson V, Klein A. Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients. BMC Cancer. 2018;18(1):304.
Sternberg SS, Mills SE, Carter D. Disorders of soft tissue Sternberg’s diagnostic surgical pathology. 3rd ed. Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2004.
Doyle LA. Surgical Pathology of Sarcomas. Pathobiology of Human Disease. 2014;3546-62.
Chowdhry V, Goldberg S, DeLaney TF, Cote GM, Chebib I, Kim J, Lozano-Calderón SA, De Amorim Bernstein K. Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy. Sarcoma. 2018;8029157.
Medscape. Diagnosis and Management of Liposarcoma, 2021. Available at: https://www.medscape. com/viewarticle/483593_2. Accessed on 08 June 2022.
Sonoda A, Sawayama H, Miyanari N, Mizumoto T, Kubota T, Baba H. Giant myxoid liposarcoma of the stomach: Report of a case. Int J Surg Case Rep. 2019;60:234-8.
ESMO. Soft Tissue and Visceral Sarcomas, 2021. Available at: https://www.esmo.org/guidelines/ guidelines-by-topic/sarcoma-and-gist/soft-tissueand-visceral-sarcomas. Accessed on 08 June 2022.
Albujar-Ching YT, Salazar-Loconi W, Hoyos Arrascue J, Ramírez V. Myxoid liposarcoma in lung. Rev Cuerpo Méd Hosp Nac Almanzor Aguinaga Asenjo. 2016;9(4):257-60.
Carrillo B JA, Navarrete C, López Arias MA, Peláez M. Primary pleural liposarcoma, pleomorphic variant. J Thorac Dis. 2014;6(9):E166-8.
