The effect of ethanolic extract of premature Musa Paradisiaca (plantain) pulp on the histology of the liver and kidneys of female Wistar rats

Progress D. Victor; Kenneth S. Ordu; Pearl C. Ajie; Elile P. Okpara; Tamununosaki B. Ogari; Edith Reuben; I. I. Nonju; Joy W. Ekokodje; Chisom F. Wami-Amadi

doi:10.18203/2320-6012.ijrms20230564

Authors

Progress D. Victor Department of Human Anatomy, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Kenneth S. Ordu Department of Human Anatomy, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Pearl C. Ajie Department of Human Anatomy, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Elile P. Okpara Department of Human Physiology, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Tamununosaki B. Ogari Department of Human Anatomy, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Edith Reuben Department of Human Physiology, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
I. I. Nonju Department of Human Physiology, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Joy W. Ekokodje Department of Human Anatomy, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria
Chisom F. Wami-Amadi Department of Human Physiology, College of Medical Sciences, Rivers state University, Nkpolu Oroworukwo, Port Harcourt, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230564

Keywords:

Kidney, Liver, Musa paradisiaca

Abstract

Background: Premature plantain is a major component in herbal remedies used for the treatment of different ailment such as reducing blood sugar, and peptic ulcer disease. The aim of the study was to determine the effect of ethanolic extract of premature Musa paradisiaca on histology of the liver and kidneys of female Wistar rats.

Methods: Twenty female Wistar rats weighing between 180-200 g were divided into four groups. Group 1 was administered distilled water only, while groups 2, 3 and 4 were administered the ethanolic extract of premature Musa paradisiaca in low, medium, and high dose respectively for 14 days.

Results: Twenty-four hours after the last administration, all animals were sacrificed, tissues were harvested. The histological reports showed varying level of damage to the cytoarchitecture of the liver and kidney tissues of the treatment groups when compared to the control.

Conclusions: This plant may likely induce nephrotoxic and hepatotoxic changes.

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