Beliefs regarding SARS-COV-2 vaccine in patients with transfusion-dependent thalassemia

Authors

  • Shruti Kakkar Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Pranjl Sharma Department of Community Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Sukhmani Sidhu Intern, Dayanand Medical College and Hospital, Ludhiana, Punjab, Indi
  • Shaina Kamboj MBBS Student, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Suraj Luthra MBBS Student, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Rashmi Kapoor Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Priyanka Dewan Child Psychologist, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20222528

Keywords:

SARS-CoV-2, Transfusion dependent thalassemia, Vaccine acceptance, Vaccine hesitancy

Abstract

Background: SARS-CoV-2 vaccination drive generated varying responses in the general public. This study aimed to assess the vaccination acceptance amongst patients with thalassemia and to elucidate their beliefs regarding SARS-CoV-2 vaccines.

Methods: A prospective observational study was done involving thalassemia patients above the age of 18 years in the thalassemia day care center of our hospital.

Results: The study assessed 145 patients with a male to female ratio of 1.5:1 and a mean age of 25.6±6 years. Seventy-six (52.4%) of the study population had already been vaccinated with the first dose, 25.5% (n=37) were willing to get vaccinated, however, 22% were vaccine-hesitant. Vaccine hesitancy was 25.5% in males compared to 16.9% in females. The fear of adverse effects to the vaccine is a major deterrent to the vaccination. Patients considered themselves at high risk of COVID-19 disease and adverse effects of the SARS-CoV-2 vaccine.

Conclusions: Vaccine hesitancy was observed in 22% of patients. A significantly higher proportion of these patients considered vaccines unsafe and ineffective. Public sharing of safety and efficacy data may help in improving trust in the vaccine. 

References

COVID live- Coronavirus statistics- worldometer. Worldometers.info. Available from: https://www.worldometers.info/coronavirus/. Accessed on 19 March 2022.

Wikipedia contributors. COVID-19 vaccine. Wikipedia, The Free Encyclopedia. 2022. Available from: https://en.wikipedia.org/w/index.php? title=COVID-19_vaccine&oldid=1077830751. Accessed on 19 March 2022.

MoHFW.gov.in. total vaccination. Available from: https://www.mohfw.gov.in/. Accessed on 19 March 2022.

MacDonald NE. Vaccine hesitancy: definition, scope, and determinants. Vaccine. 2015;33(34):4161-4.

Kumar D, Chandra R, Mathur M, Samdariya S, Kapoor N. Vaccine hesitancy: understanding better to address better. Isr J Health Policy Res. 2016;5(1):2.

Chandani S, Jani D, Sahu PK, Kataria U, Suryawanshi S, Khubchandani J, et al. COVID-19 vaccination hesitancy in India: State of the nation and priorities for research. Brain Behav Immun Health. 2021;18(100375):100375.

Chowdhury SR, Motheram A, Pramanik S. Covid-19 vaccine hesitancy: Trends across states, over time. Ideas For India. Available from: https://www.ideasforindia.in/topics/human-development/covid-19-vaccine-hesitancy-trends-across-states-over-time.html. Accessed on 19 March 2022.

Colah R, Italia K, Gorakshakar A. Burden of thalassemia in India: The road map for control. Pediatr Hematol Oncol J. 2017;2(4):79-84.

Karimi M, Haghpanah S, Azarkeivan A, Zahedi Z, Zarei T, Akhavan Tavakoli M, et al. Prevalence and mortality in β-thalassaemias due to outbreak of novel coronavirus disease (COVID-19): the nationwide Iranian experience. Br J Haematol. 2020;190(3):e137-40.

Zafari M, Rad MTS, Mohseni F, Nikbakht N. Β-thalassemia major and coronavirus-19, mortality and morbidity: a systematic review study. Hemoglobin. 2021;45(1):1-4.

Alqudeimat Y, Alenezi D, AlHajri B, Alfouzan H, Almokhaizeem Z, Altamimi S, et al. Acceptance of a COVID-19 vaccine and its related determinants among the general adult population in Kuwait. Med Princ Pract. 2021;30(3):262-71.

Suresh A, Konwarh R, Singh AP, Tiwari AK. Public awareness and acceptance of COVID-19 vaccine: An online cross-sectional survey, conducted in the first phase of vaccination drive in India. Res Square. 2021.

Huynh G, Van Nguyen T, Nguyen DD, Lam QM, Pham TN, Nguyen HTN. Knowledge about COVID-19, beliefs, and vaccination acceptance against COVID-19 among high-risk people in Ho Chi Minh city, Vietnam. Infect Drug Resist. 2021;14:1773-80.

Troiano G, Nardi A. Vaccine hesitancy in the era of COVID-19. Public Health. 2021;194:245-51.

Syed Alwi SAR, Rafidah E, Zurraini A, Juslina O, Brohi IB, Lukas S. A survey on COVID-19 vaccine acceptance and concern among Malaysians. BMC Public Health. 2021;21(1):1129.

Al-Qerem WA, Jarab AS. COVID-19 vaccination acceptance and its associated factors among a middle eastern population. Front Public Health. 2021;9:632914.

Kuppalli K, Brett-Major DM, Smith TC. COVID-19 vaccine acceptance: we need to start now. Open Forum Infect Dis. 2021;8(2):ofaa658.

Dzieciolowska S, Hamel D, Gadio S, Dionne M, Gagnon D, Robitaille L, et al. Covid-19 vaccine acceptance, hesitancy, and refusal among Canadian healthcare workers: A multicenter survey. Am J Infect Control. 2021;49(9):1152-7.

Paudel S, Palaian S, Shankar PR, Subedi N. Risk perception and hesitancy toward COVID-19 vaccination among healthcare workers and staff at a medical college in Nepal. Risk Manag Healthcare Policy. 2021;14:2253-61.

Jain J, Saurabh S, Kumar P, Verma MK, Goel AD, Gupta MK, et al. COVID-19 vaccine hesitancy among medical students in India. Epidemiol Infect. 2021;149(e132):e132.

Times Now. Vaccine hesitancy: People flee the village fearing Covid vaccination. Economic Times. 2021. Available from: https://economictimes. indiatimes.com/news/India/vaccine-hesitancy-people-flee-village-fearing-covid-vaccination/videoshow/88564565.cms. Accessed on 19 March 2022.

Building confidence in the COVID-19 vaccine in India. Unicef.org. Available from: https://www. unicef.org/india/stories/building-confidence-covid-19-vaccine-India. Accessed on 19 March 2022.

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Published

2022-09-27

How to Cite

Kakkar, S., Sharma, P., Sidhu, S., Kamboj, S., Luthra, S., Kapoor, R., & Dewan, P. (2022). Beliefs regarding SARS-COV-2 vaccine in patients with transfusion-dependent thalassemia. International Journal of Research in Medical Sciences, 10(10), 2230–2235. https://doi.org/10.18203/2320-6012.ijrms20222528

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Original Research Articles