Comparison of two palliative regimens of radiation on the quality of life in metastatic non small cell lung cancer

Tarun J. Singh; Gurpreet K. Taggar; Vikas Fotedhar; Manish Gupta; Siddharth Vats

doi:10.18203/2320-6012.ijrms20230169

Authors

Tarun J. Singh Department of Radiotherapy and Oncology, Dr. Y. S. Parmar Medical College, Nahan, Sirmour, Himachal Pradesh, India
Gurpreet K. Taggar Department of Immunohematology and Blood Transfusion, Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India
Vikas Fotedhar Department of Radiotherapy and Oncology, Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India
Manish Gupta Department of Radiotherapy and Oncology, Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India
Siddharth Vats Department of Radiotherapy and Oncology, Indira Gandhi Medical College and Hospital, Shimla, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230169

Keywords:

Lung cancer, Stage IV NSCLC, Quality of life, EORTC-QLQ C30, Locally advanced lung cancer, Metastatic lung cancer

Abstract

Background: Lung cancer is one of the most common cancers in males worldwide and its number is increasing every year. Of these cases 75-80% case are of non-small cell type.

Methods: This study was conducted on 30 patients of stage IV non-small cell lung cancer in the department of radiation oncology at tertiary care center, Shimla, Himachal Pradesh India from 1^st Jun 2019 to 30^th Jun 2020 by dividing them into study and control arm for assessing quality of life (QOL) with EORTC QLQ-C30 version3.0.

Results: We observed significant improvement in Global health scale of control arm (p=0.005) but it got worse in study arm (p=0.743). All the parameters of Functional scale i.e. Physical (p=0.584; 0.170), Role (p=0.213; 0.016), Emotional (p=0.239; 0.002), Cognitive (p=0.793; 0.247) and Social functioning (p=0.030; 0.231) got worse in study arm while they improved in control arm. As far as Symptom scale is concerned, in the study arm; dyspnea (p=0.724), appetite (p=0.836), constipation (0.192), diarrhea (p=0.341) improved but other symptoms like fatigue (p=0.566), nausea (p=0.347), pain (p=0.305), insomnia (p=0.025), financial difficulties (p=0.082) got worse while in control arm; fatigue (p=0.003), pain (p=0.000), dyspnea (p=0.022), insomnia (p=0.336), appetite (p=0.028), constipation (0.019), diarrhea (p=0.336), financial difficulties (p=0.336) improved and nausea (p=0.120) got worse.

Conclusion: QOL assessment by the physician before commencement of the treatment and later on at every visit seems to be beneficial for symptom relief and to allay the anxiety of both patient and their attendants.

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