Management of epidermal hyperpigmentation with a novel depigmenting formulation: a research survey
DOI:
https://doi.org/10.18203/2320-6012.ijrms20232794Keywords:
Depigmenting formulation, Epidermal hyperpigmentation, Kojic acidAbstract
Background: Epidermal hyperpigmentation is an important dermatological concern with a high prevalence in the Indian population. Kojic acid-based depigmenting formulations have proven to be effective in the management of epidermal hyperpigmentation. A questionnaire-based survey was conducted to assess physicians’ knowledge about epidermal hyperpigmentation and practice patterns about a novel depigmenting formulation containing a combination of kojic acid dipalmitate 4%, azelaic acid 12%, glycolic acid 3%, niacinamide 4%, arbutin 2%, glycogen liquid 2%, sodium hyaluronate solution 2%, and shea butter 1% for epidermal hyperpigmentation treatment in India.
Methods: The survey was conducted among 235 dermatologists across different geographical regions of India over 3 months. The questionnaire evaluated prevalence and choice and duration of therapies for epidermal hyperpigmentation in Indian clinical practice, and dermatologists’ real-life experience with efficacy of the novel formulation. Descriptive statistics were used to summarize survey results.
Results: All 235 dermatologists completed the questionnaire and responded to questions based on experience in treating patients with epidermal hyperpigmentation. In all, 58% dermatologists preferred kojic acid-based combinations. Furthermore, 57% of dermatologists agreed that glycolic acid can enhance the penetration of kojic acid and azelaic acid, 47.45% strongly agreed that a kojic acid-based formulation could be a safe alternative to steroid and hydroquinone-based formulations. Overall, 67% of dermatologists agreed that the kojic acid-based formulations with additional moisturizers helped in faster resolution of epidermal hyperpigmentation compared to other depigmenting formulations.
Conclusions: The survey findings indicate that the novel kojic acid-based formulation with additional moisturizers could be a preferred choice for epidermal hyperpigmentation management.
Metrics
References
Nouveau S, Agrawal D, Kohli M, Bernerd F, Misra N, Nayak CS. Skin hyperpigmentation in Indian Population: Insights and best practice. Indian J Dermatol. 2016;61:487-95.
Adil M, Amin SS, Arif T, Dorjay K, Raj RD, Bansal R. Hyperpigmented skin conditions: a study of pattern and prevalence from a tertiary care hospital of North India. Int J Curr Adv Res. 2017;6:3562-5.
Taylor S, Grimes P, Lim J, Im S, Lui H. Postinflammatory hyperpigmentation. J Cutan Med Surg. 2009;13:183-91.
Shin JW, Park KC. Current clinical use of depigmenting agents. Dermatol Sin. 2014;32:205-10.
Davis EC, Callender VD. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. J Clin Aesthet Dermatol. 2010;3:20-31.
Callender VD, Surin-Lord SS, Davis EC, Maclin M. Postinflammatory hyperpigmentation. Am J Clin Dermatol. 2011;12:87-99.
Nayak CS, Ansari SMM, Salve V, Patil S. Effectiveness of a combination of anti-pigmentary products in facial post-inflammatory hyperpigmentation. Int J Res Dermatol. 2020;6:1-8.
Sarkar R, Arora P, Garg KV. Cosmeceuticals for hyperpigmentation: What is available? J Cutan Aesthet Surg. 2013;6:4-11.
Juncan AM, Moisă DG, Santini A, Morgovan C, Rus LL, Vonica-Țincu AL, et al. Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals. Molecules. 2021;26:4429.
Draelos ZD, Diaz I, Namkoong J, Wu J, Boyd T. Efficacy evaluation of a topical hyaluronic acid serum in facial photoaging. Dermatol Ther. 2021;11:1385-94.
Chandrashekar B, Chaithra S, Lakshmi NN. Effectiveness and safety of a novel topical depigmenting agent in epidermal pigmentation: an open-label, non-comparative study. Int J Res Dermatol. 2018;4:489-94.
Ortonne JP, Bissett DL. Latest insights into skin hyperpigmentation. J Investig Dermatol Symp Proc 2008;13:10-4.
Lawrence E, Al Aboud KM. Postinflammatory Hyperpigmentation. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559150/. Accessed 3 October 2021.
Hollinger JC, Angra K, Halder RM. Are natural ingredients effective in the management of hyperpigmentation? A systematic review. J Clin Aesthet Dermatol. 2018;11:28-37.
Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a new topical nano-hyaluronic acid in humans. J Clin Aesthet Dermatol. 2014;7:27-9.
Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 2017;19:70.
Downloads
Published
How to Cite
Issue
Section
