Distribution of influenza A and B antibodies and correlation with ABO/Rh blood grouping


  • Abdulrahim R. Hakami Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
  • Abdullah J. Alshahrani Department of Public Health, General Directorate of Health Affairs in Asir Region, Abha, Saudi Arabia
  • Osama A. Alshehri Public Health Laboratory, Public Health Authority, Riyadh, Saudi Arabia
  • Ahmed Saif Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia
  • Ahmad A. Alshehri Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia http://orcid.org/0000-0002-3143-3023




Anti-influenza antibodies, Blood groups, Flu vaccine


Background: Influenza is a clinically-significant infection with significant number of globally reported annual deaths. The aim of this study was to study the distribution of influenza A and B antibodies in Najran, the Southwest region of Saudi Arabia, and to investigate the correlation between demographic characteristics and influenza virus antibody levels.

Methods: Enzyme linked immunosorbent assay was used to detect antibody level of influenza A and B. The correlation with ABO/Rh blood groupings was also examined. The total number of participants was 252. Only twenty-four subjects received the flu vaccine.

Results: It was found that 33.7% and 24.1% of unvaccinated subjects were IgG-positive for influenza A and B, respectively. Interestingly, the antibody levels of the unvaccinated participants were higher than the vaccinated group. A significant difference was found between unvaccinated participants with O+ and influenza A and B antibody levels (**p=0.0045). The antibody level was inversely correlated with age in influenza B IgG subjects but not influenza A IgG (r=-0.1379; R squared=0.01900; p=0.0375). Forty-three subjects (17%) were positive for antibodies of both influenza A and B.

Conclusions: IgG antibody positivity is greater in cases of influenza type A compared to influenza B. A significant correlation was found in the unvaccinated group between influenza B IgG antibody levels and age, but not influenza A (*p=0.0375). More research is needed to investigate the role of O+ blood group in influenza infections.


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How to Cite

Hakami, A. R., Alshahrani, A. J., Alshehri, O. A., Saif, A., & Alshehri, A. A. (2022). Distribution of influenza A and B antibodies and correlation with ABO/Rh blood grouping. International Journal of Research in Medical Sciences, 10(12), 2724–2730. https://doi.org/10.18203/2320-6012.ijrms20222965



Original Research Articles