Assessment of oxidative stress in serum of pulmonary tuberculosis patients

Vishal Wagh; Shreewardhan Rajopadhye; Sandeepan Mukherjee; Anant Urhekar; Deepak Modi

doi:10.18203/2320-6012.ijrms20162288

Authors

Vishal Wagh Department of Microbiology, MGM Institute of Health Sciences, Navi Mumbai, Maharashtra
Shreewardhan Rajopadhye Haffkine Institute for Training, Research and Testing, Mumbai, Maharashtra
Sandeepan Mukherjee Haffkine Institute for Training, Research and Testing, Mumbai, Maharashtra
Anant Urhekar Department of Microbiology, MGM Institute of Health Sciences, Navi Mumbai, Maharashtra
Deepak Modi National Institute of Research in Reproductive Health, Mumbai, Maharashtra

DOI:

https://doi.org/10.18203/2320-6012.ijrms20162288

Keywords:

Tuberculosis, Oxidative stress, TBARS, Nitric oxide, GSH

Abstract

Background: Tuberculosis (TB) remains a human health issue and often deadly infectious disease in low-middle income nations. In TB, oxidative stress is a result of tissue inflammation, poor dietary intake of micronutrients due to illness, free radical burst from activated macrophages. This study was conducted prospectively to evaluate the oxidative stress in TB.

Methods: The study included 30 newly diagnosed TB positive patients and 30 healthy individuals. Pro-oxidant markers like the thiobarbituric acid reactive species (TBARS) and nitric oxide were studied from serum. Antioxidant parameter like serum total-SH was also assessed.

Results: Levels of pro-oxidants were significantly increased whereas antioxidant defense markers were significantly impaired in the TB group. Nitric oxide and TBARS were increased (p<0.0001) where glutathione was decreased (p<0.0001) in TB population compared to healthy controls.

Conclusions: Marked oxidative stress were seen in the TB population as compared to the healthy cohort. The role of antioxidant therapy may therefore be evaluated in the management of TB.

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