An unusual cross reactivity between hydrochlorothiazide and para-phenylenediamine: a case report

Deena Patil; Tharayil K. Sumathy; Hassan V. Anuradha

doi:10.18203/2320-6012.ijrms20223106

Authors

Deena Patil Department of Dermatology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India http://orcid.org/0000-0001-6845-1244
Tharayil K. Sumathy Department of Dermatology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India
Hassan V. Anuradha Department of Pharmacology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20223106

Keywords:

Cross-reaction, Para-phenylenediamine, Hydrochlorothiazide, Hair dye, Contact dermatitis

Abstract

Over the last decade, the usage of hair color is gradually increasing from adolescents to the geriatric population. In the elderly population, more use of hair color due to graying of hairs exposes them to chemicals such as para-phenylenediamine (PPD). Many cases are reported regarding various manifestations of allergic contact dermatitis due to PPD compound present in hair color. It is noteworthy that, in the elderly the use of antidiabetics and antihypertensives, makes them vulnerable to cross-reaction or interaction with drugs and chemicals. We report a case that highlights the adverse reaction to hydrochlorothiazide in a PPD sensitive individual.

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