Drug utilization study of patients with dermatophytosis attending dermatology outpatient department in tertiary care teaching hospital in Central India

Vandana A. Badar; Parul Gaikwad; Kalyani Pradhan; Rachana Chavan

doi:10.18203/2320-6012.ijrms20231642

Authors

Vandana A. Badar Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
Parul Gaikwad Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
Kalyani Pradhan Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
Rachana Chavan Department of Pharmacology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231642

Keywords:

Dermatophytosis, Drug utilisation study, Antifungal agents, Terbinafine

Abstract

Background: Dermatophytosis is a common fungal infection in India, with prevalence ranging from 36.6% to 78.4%. Treatment options include topical and systemic antifungal agents such as amphotericin B, clotrimazole, miconazole, luliconazole, itraconazole, and terbinafine. With the availability of newer antifungal drugs, a drug utilization study is necessary to understand prescription patterns and promote rational use.

Methods: This is a retrospective observational study conducted among the patients attending outpatient department of dermatology of Indira Gandhi Government Medical College and Mayo Hospital. Prescription of patients with diagnosis of tinea were collected using efficient digital database. These prescriptions were then analysed depending on their demographic profile, treatment and then results were evaluated with the help of MS Excel and results presented as percentage and proportion.

Results: Total 3701 patients had tinea with 1658 females and 2043 males with majority of patients from 16 to 30 years of age. 81% medicine were prescribed using brand names with prescription containing maximum antifungal drugs followed by antihistaminic drugs. Most common drug prescribed was terbinafine (29%), followed by luliconazole (27.46%) and itraconazole (17%). Most commonly topical antifungal agents were prescribed as cream (35.80%) followed by as lotion (26.26%).

Conclusions: Drug utilisation pattern study like this is very important for studying the varying prescription pattern in treatment of dermatophytosis and to make a first step towards uniform and rational drug prescription.

Metrics

Metrics Loading ...

References

Barker J, Bleiker TO, Chalmers R, Griffiths CE, Creamer D. Rook's textbook of dermatology. USA: John Wiley & Sons; 2016.

Falah AK. Dermatophytosis a worldwide contiguous fungal infection growing challenge and few solutions. Biomed Biotechnol Res J. 2020;12:103-6.

Fauci AS. Harrison's principles of internal medicine. USA: Mcgraw-Hill Education; 2015.

Naglot A, Shrimali DD, Nath BK, Gogoi HK, Veer V, Chander J, et al. Recent trends of dermatophytosis in Northeast India (Assam) and interpretation with published studies. Int J Curr Microbiol App Sci. 2015; 4(11):111-20.

Sahoo AK, Mahajan R. Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian Dermatol J. 2016;7(2):77.

Drake LA, Dinehart SM, Farmer ER, Goltz RW, Graham GF, Hardinsky MK, et al. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. Guidelines/Outcomes Committee. American Academy of Dermatology. J Am Acad Dermatol. 1996;34(2):282-6.

Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008;51:2-15.

Dhaher S. Tinea incognito: Clinical perspectives of a new imitator. Dermatol Rep. 2020;12(1):23.

Rajagopalan M, Inamadar A, Mittal A, Miskeen AK, Srinivas CR, Sardana K, et al. Expert consensus on the management of dermatophytosis in India (ECTODERM India). BMC Dermatol. 2018;18(1):1.

Moriarty B, Hay R, Morris-Jones R. The diagnosis and management of tinea. BMJ. 2012 ;10:345.

Goodman L, Gilman A, Brunton L, Hilaldandan R. Prescription Order Writing and Patient Compliance. Goodman & Gilman's the pharmacological basis of therapeutics. 13th ed. New York: Mcgraw-Hill Education; 2018.

Shalini S, Ravichandran V, Saraswathi R, Mohanty BK, Dhanaraj SK. Drug utilization studies–an overview. Int J Pharm Sci Nanotech. 2010;3(1):803-10.

How to investigate drug use in health facilities: selected drug indicators, action program on essential drugs (DAP), Geneva, 1993. Available at: http://apps.who.int/medicinedocs/en/d/Js2289e/. Accessed on 20 November 2022.

Koshley V, Halwai AK, Koshley SB, Kurrey PK, Jaiswal S. Treatment Pattern of dermatophytosis at the outpatient clinic of a tertiary healthcare hospital of Chhattisgarh, Central India. Indian J Clin Experi Dermatol. 2018;4(4):327- 30.

Chaudhary RG, Rathod SP, Jagati A, Baxi K, Ambasana A, Patel D. Prescription and usage pattern of topical corticosteroids among out-patient attendees with dermatophyte infections and its analysis: A cross-sectional, survey-based study. Indian Dermatol J. 2019;10(3):279.

Sougata M, Bagchi C, Chatterjee K. An OPD based prospective exploratory study of dermatophytosis - focus on treatment outcomes, Medication adherence, and quality of life. Asian J Pharma Clin Res. 2021; 10:109-12.

Giri VP, Giri OP. Drug prescribing pattern in dermatophytosis at the medical outpatient clinic of a tertiary healthcare in Karnataka, India. Med Sci. 2015;4:1-8.

Narang T, Dogra S, Singh S. Disease burden and prescription patterns treating dermatophytosis in North India:salient findings from an online survey of 1041 dermatologists. Indian Dermatol J. 2018;8(2):187.

Kamerkar SA. Prescription pattern and the cost analysis of tinea and acne patients in the dermatology department of a tertiary care teaching hospital. Indian J Clin Experi Dermatol. 2015;2(5):234-8.

Pathak A, Kumar S, Harihar D. Study of drug utilization pattern for skin diseases in dermatology OPD of an Indian Tertiary Care Hospital - A Prescription Survey. J Clin Diag Res. 2016;10:FC01-5.