Relationship of depth of invasion of tumour with neck node metastasis in oral squamous cell carcinoma: a clinico pathological correlation

Authors

  • Arjun Roy Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India
  • Mridul Kumar Sarma Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India
  • Muktanjalee Deka Department of Oncopathology, State Cancer Institute, GMC, Guwahati, Assam, India
  • Ajit Kumar Missong Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati, Assam, India
  • Mrinmoy Mayur Choudhury Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati, Assam, India
  • Yousuf F. Choudhury Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20223308

Keywords:

Invasion, Metastasis, Squamous cell carcinoma

Abstract

Background: Squamous cell carcinomas of the oral cavity are relatively common among the head and neck cancers. The increasing depth of invasion (DOI) and the microvascular proliferation caused by neoplastic growth might determine proximity to blood vessels and lymphatics, thus facilitating the tumor’s ability to metastasize. The role of tumour DOI as a prognostic parameter for the development of nodal metastases and for the survival of patients with OSCC are important. Aim of the study was to determine the relationship of the DOI of tumor with the neck node metastasis in squamous cell carcinoma of the oral cavity.

Methods: This study is conducted in the State cancer institute, Gauhati medical college over a period of 1 year from June 2021 to June 2022 among 100 patients. All patients underwent tumor resection with neck dissection, and the DOI is measured.

Results: Out of 100 patients included in the study 66 were males and 34 were females. Maximum number of cases 30% were seen in the age group of 51-60 years. Gingivobuccal sulcus (32%) is the most commonly involved site. Maximum number of nodal meta-stasis present in tumours with DOI>11 mm and minimum nodal metastasis present in tumours with DOI<3 mm.   

Conclusions: We conclude that tumor DOI is significantly related with neck nodal metastasis in oral cavity squamous cell carcinoma.

Author Biographies

Arjun Roy, Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

Fellow, Head & Neck Oncology, State Cancer Institute, GMC, Guwahati

Mridul Kumar Sarma, Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

Associate Professor, Department of Head & Neck Oncology, State Cancer Institute, GMC, Guwahati

Muktanjalee Deka, Department of Oncopathology, State Cancer Institute, GMC, Guwahati, Assam, India

Professor & HOD, Department of Oncopathology, State Cancer Institute, GMC, Guwahati

Ajit Kumar Missong, Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

Assistant Professor, Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati

Mrinmoy Mayur Choudhury, Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

Assistant Professor, Department of Surgical Oncology, State Cancer Institute, GMC, Guwahati

Yousuf F. Choudhury, Department of Head and Neck Oncology, State Cancer Institute, GMC, Guwahati, Assam, India

Fellow, Head & Neck Oncology, State Cancer Institute, GMC, Guwahati

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Published

2022-12-30

How to Cite

Roy, A., Sarma, M. K., Deka, M., Missong, A. K., Choudhury, M. M., & Choudhury, Y. F. (2022). Relationship of depth of invasion of tumour with neck node metastasis in oral squamous cell carcinoma: a clinico pathological correlation. International Journal of Research in Medical Sciences, 11(1), 69–73. https://doi.org/10.18203/2320-6012.ijrms20223308

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Original Research Articles