Gasserian ganglion metastases of oral squamous cell carcinoma in the absence of loco-regional metastases masquerading as trigeminal neuralgia

Akriti Saxena; Niti Singhal; Ashutosh Rath; Vivekanand Singh; Ravi Shankar; Madhu Mati Goel

doi:10.18203/2320-6012.ijrms20231362

Authors

Akriti Saxena Department of Pathology and Lab Medicine, Medanta Hospital, Lucknow, Uttar Pradesh, India
Niti Singhal Department of Pathology and Lab Medicine, Medanta Hospital, Lucknow, Uttar Pradesh, India
Ashutosh Rath AIIMS, Bibi Nagar, Telangana, India
Vivekanand Singh Department of Head and Neck Surgical Oncology, Medanta Hospital, Lucknow, Uttar Pradesh, India
Ravi Shankar Department of Neurosurgery, Medanta Hospital, Lucknow, Uttar Pradesh, India
Madhu Mati Goel Department of Pathology and Lab Medicine, Medanta Hospital, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231362

Keywords:

Trigeminal neuralgia, Schwannoma, Squamous cell carcinoma metastasis, Gasserian ganglion

Abstract

We presented an unusual case of a 43-year-old man presenting with symptoms of trigeminal neuralgia with a clinico-radiological diagnosis of maxillary nerve schwannoma. Surgical excision and histopathology revealed a diagnosis of metastases of squamous cell carcinoma to Gasserian ganglion. On further investigation, the primary tumour was detected in the right alveolar region of mandible. Our purpose of presenting this case was to make the clinicians aware that all cases presenting with trigeminal neuralgia may not be benign and may be the sole presentation of brain metastases of oral cancer without the loco-regional spread.

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References

Binmadi NO, Basile JR. Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol. 2011;47(11):1005-10.

Liebig C, Ayala G, Wilks JA, Berger DH, Albo D. Perineural invasion in cancer: a review of the literature. Cancer. 2009;115(15):3379-91.

Mendenhall WM, Amdur RJ, Hinerman RW, Werning JW, Malyapa RS, Villaret DB, et al. Skin cancer of the head and neck with perineural invasion. Am J Clin Oncol. 2007;30(1):93-6.

Ballantyne AJ, McCarten AB, Ibanez ML. The extension of cancer of the head and neck through peripheral nerves. Am J Surg. 1963;106(4):651-67.

Boerman RH, Maassen EM, Joosten J, Kaanders HA, Marres HA, van Overbeeke J, et al. Trigeminal neuropathy secondary to perineural invasion of head and neck carcinomas. Neurology. 1999;53(1):213.

Gronseth G, Cruccu G, Alksne J, Argoff C, Brainin M, Burchiel K, et al. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008;71(15):1183-90.

Agarwal A. Intracranial trigeminal schwannoma. Neuroradiol J. 2015;28(1):35-41.

Li S, Sun, Gao D. Role of the nervous system in cancer metastasis. Oncol Letter. 2013;5(4):1101-11.

Rao NR, Villa A, More CB, Jayasinghe RD, Kerr AR, Johnson NW. Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management. J Otolaryngol Head Neck Surg. 2020;49(1):1.