Histomorphological spectrum of gastrointestinal stromal tumors: an institutional experience

Authors

  • Vajja Nagaraju Department of Pathology, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India
  • Shilpa M. Doddagowda Department of Pathology, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India http://orcid.org/0000-0003-4038-1269
  • Hemalatha Anantharamiah Department of Pathology, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India
  • Malligere Lingaiah Harendra Kumar Department of Pathology, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India
  • Patrapalle Nadipanna Sreeramulu Department of Surgery, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20223300

Keywords:

Mitotic count, c-KIT, DOG-1, Immunohistochemical markers

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the abdominal area. They can involve any portion of the gastrointestinal (GI) tract, omentum, mesentery, retroperitoneum, and other sites. They form 1-2% of the histologic types of gastrointestinal tract tumors. Aims and objectives were to analyze and correlate morphological, clinical and histomorphology features of gastrointestinal tumors presenting at different sites.

Methods: This was a retrospective observational study for six years. Medical records of the histopathologically diagnosed GIST cases were reviewed for patient demographics and clinical presentation, and tumor findings were noted.

Results: Of the 28 patients, ages ranged from 28 to 80 years. Symptoms ranged from abdominal pain, epigastric discomfort, mass, upper/lower gastrointestinal bleeding, rectal bleeding, anemia, weight loss, and small bowel obstruction. Sites involved were the small bowel, stomach, mesentery, rectum, duodenum, greater omentum, and retroperitoneum. Of 28 cases of GIST, 25 cases showed both c-KIT and DOG-1 positivity, 1 case showed only c-KIT positivity, 1 case showed only DOG-1 positivity, and 1 case was both c-KIT and DOG-1 negative.

Conclusions: GISTS are unpredictable mesenchymal tumors. Common sites are the stomach and small gut. Mesenteric and omental GIST are rare. Spindle cell morphology was more commonly present.

Author Biography

Shilpa M. Doddagowda, Department of Pathology, Sri Devaraj Urs Medical College Affiliated to Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

Department of Pathology

Associate Professor

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Published

2022-12-30

How to Cite

Nagaraju, V., Doddagowda, S. M., Anantharamiah, H., Harendra Kumar, M. L., & Sreeramulu, P. N. (2022). Histomorphological spectrum of gastrointestinal stromal tumors: an institutional experience. International Journal of Research in Medical Sciences, 11(1), 107–112. https://doi.org/10.18203/2320-6012.ijrms20223300

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Original Research Articles