Prevalence of splenomegaly and factors contributing to splenomegaly among pancytopenia patients: a facility-based cross-sectional study

Kaushik N.; Basanth Kumar S.; Vedavathi R.

doi:10.18203/2320-6012.ijrms20230580

Authors

Kaushik N. Department of General Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India
Basanth Kumar S. Department of General Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India
Vedavathi R. Department of General Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230580

Keywords:

Pancytopenia, Splenomegaly, Hematology

Abstract

Background: The spleen is an organ that cannot be clinically felt in a normal individual. Splenomegaly is a significant diagnostic indicator of the presence of underlying pathology. It is associated with a number of diseases like hematological, infectious, portal hypertension and immunological problems. However, it’s unclear what exactly causes hypersplenism. The objective was to assess the prevalence of splenomegaly in people with pancytopenia and the contributing factors.

Methods: A cross-sectional study was conducted among adult patients diagnosed with pancytopenia in a tertiary care hospital in Bengaluru, Karnataka. We have considered only inpatients who accessed care at the facility over a period of 12 months from Aug 2021 to July 2022 among those who have given written informed consent. Socio-demographic details, smoking status, alcohol consumption history, existing comorbidities, and other biological parameters were assessed by accessing the medical records. The abdominal ultrasound of the admitted patients was used to diagnose splenomegaly.

Results: Splenomegaly was present in 25 (56.8%) of patients out of 44 we enrolled. Among those patients, 17 (38.6%) had mild, while 4 (9.1%) had moderate and massive splenomegaly respectively. The majority were females (28 versus 16 males) and the mean age was 44.84 years (±15.45 SD). The age ranges from 24-80 years. We observed that patients aged 36-50 years and comorbidities like hypertension and hypothyroidism were the associated factors for splenomegaly.

Conclusions: The prevalence of splenomegaly among pancytopenia patients is high. This is a significant clinical indication that requires careful investigation. Ageing, hypertension, and hypothyroidism are contributory factors for splenomegaly in patients with pancytopenia.

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References

Vargas-Carretero CJ, Fernandez-Vargas OE, Ron-Magaña AL, Padilla-Ortega JA, Ron-Guerrero CS, Barrera-Chairez EJH. Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature. Hematology. 2019;24(1):399-404.

Makheja KD, Maheshwari BK, Arain S, Kumar S, Kumari SJ. The common causes leading to pancytopenia in patients presenting to tertiary care hospital. Pak J Med Sci. 2013;29(5):1108.

Rao KS. Pancytopenia: a clinico hematological study. J Lab Phys. 2011;3(01):015-20.

Kumar V, Khare M, Kishore M, Sharma M, Marwah S, Nigam A, et al. Diagnostic approach of new-onset pancytopenia: study from a tertiary care center. Ann Pathol Lab Med. 2018;5.

Knott DL. Splenomegaly and Hypersplenism. Patient. Available from: https://patient.info/doctor/splenomegaly-and-hypersplenism. Accessed on 2 July 2022.

Ali A. Causes of gross splenomegaly in Yemen. Clinical MD Thesis (KU). 1997.

Hosey RG, Mattacola CG, Kriss V, Armsey T, Quarles J, Jagger J. Ultrasound assessment of spleen size in collegiate athletes. Br J Sport Med. 2006;40(3):251-4.

Lakhani JD, Gill R, Mehta D, Lakhani SJ. Prevalence of splenomegaly and splenic complications in adults with sickle cell disease and its relation to fetal hemoglobin. Int J Hematol Oncol Stem Cell Res. 2022.

Furrer H, Swiss HIV Cohort Study. Prevalence and clinical significance of splenomegaly in asymptomatic human immunodeficiency virus type 1-infected adults. Clin Infect Dis. 2000;30(6):943-5.

O'Reilly RA. Splenomegaly in 2,505 patients at a large university medical center from 1913 to 1995. 1963 to 1995: 449 patients. West J Med. 1998;169(2):88.

Charlotte EE, Nicole AYA, Yolande DP, Line CK, Edgar MML, Foute FNN, et al. Factors associated with splenomegaly amongst patients with sickle cell disease in Cameroon. Open J Pediatr. 2022;12(1):33-46.