A cross sectional study to determine the correlation of blood glucose and HbA1C in type 2 diabetes mellitus patients
DOI:
https://doi.org/10.18203/2320-6012.ijrms20230337Keywords:
Type 2DM, FBG, PPBG, Glycosylated hemoglobinAbstract
Background: Measurement of glycosylated hemoglobin (HbA1c) is considered the gold standard for monitoring chronic glycemic level of diabetes patients. HbA1c is a form of hemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. Levels of HbA1C represent the average blood glucose levels of diabetic patients over the previous 120 days. The objective of this study was to see the correlation between HbA1c levels and glucose levels.
Methods: This cross-sectional study included 60 randomly selected subjects with known diabetes. Both fasting and post prandial blood glucose levels were measured by using venous blood samples. HbA1c levels were measured in venous blood by immunoturbidimetric method. Data were recorded on a proforma in MS-excel sheet. Pearson's coefficient of correlation was applied to find out any significant correlation between the HbA1c levels and the both fasting and postprandial blood glucose levels.
Results: Results were obtained by statistical calculation and plotted with respect to scatter and bar diagram was done and a p<0.05 was considered significant (With 95% CI).
Conclusions: A significant linear positive correlation exists between levels of HbA1C and fasting and post prandial blood glucose.
Metrics
References
World Health Organization, Global Report on Diabetes. Geneva, 2016. Available at: https://www.who.int/publications/i/item/9789241565257. Accessed on 3 June 2022.
''Simple treatment to curb diabetes''. January 20, 2014. Available at: http://www.idf.org/diabetesatlas. Accessed on 20 June 2022.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030". Diabetes Care. 2004;27(5):1047-53.
Williams textbook of endocrinology (12th ed.). Philadelphia: Elsevier/Saunders. 2015: 1371-435.
Australian Indigenous Health Info Net, Chronic conditions: Diabetes. Available at: https://www.diabetesaustralia.com.au/about-diabetes/diabetes-in-australia/. Accessed on 20 June 2022.
Diabetes facts. In: IDF Diabetes Atlas. 2011. Available at: http://www.idf.org/diabetesatlas. Accessed on 22 December 2022.
Spielmann N, Wong DT. Saliva: Diagnostics and therapeutic perspectives. Oral Dis. 2011;17:345-54.
Manfredi M, McCullough MJ, Vescovi P, Al-Kaarawi ZM, Porter SR. Update on diabetes mellitus and related oral diseases. Oral Dis. 2004;10:187-200.
Standards of Medical Care in Diabetes 2013. American Diabetes Association. 2013;2.
Ghazanfari Z, Haghdoost AA, Alizadeh SM, Atapour J, Zolala F. A comparison of HbA1c and fasting blood sugar tests in general population. Int J Prev Med. 2010;1(3):187-94.
Castilho EM, Glass ML, Manço JC. The effects of 2,3-diphosphoglycerate, adenosine triphosphate, and glycosylated hemoglobin on the hemoglobin-oxygen affinity of diabetic patients. Braz J Med Biol Res. 2003;36(6):731-7.
Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay. N Engl J Med. 1984;310(6):341-6.
Tahara Y, Shima K. The response of GHb to stepwise plasma glucose change over time in diabetic patients. Diabetes Care. 1993;16(9):1313-4.
Virtue MA, Furne JK, Nuttall FQ, Levitt MD. Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration. Diabetes Care. 2004;27(4):931-5.
Cohen RM, Franco RS, Khera PK, Smith EP, Lindsell CJ, Ciraolo PJ et al. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood. 2008;112(10):4284-91.
Rosediani M, Azidah AK, Mafauzy M. Correlation between Fasting Plasma Glucose, Post Prandial Glucose and Glycated Haemoglobin and Fructosamine. Med J Malaysia. 2006;61(1):67-71.
Stratton M, Adler AI, Neil HA, Matthews D, Manley S, Cull C. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Br M J. 2000;32(1):405-12.
KilPatrick ES, Rigby AS, Atkin SL. Variability in the relationship between mean plasma glucose and HbA1c: implications for the assessment of glycemic control. Clin Chem 2007;53:897-901.
Bloomgarden ZT. A1c: recommendations, debates, and questions. Diabetes Care. 2009;32(12):1418.
Lenters-Westra E, Slingerland RJ. Six of Eight Hemoglobin A1c Point-of-Care Instruments Do Not Meet the General Accepted Analytical Performance. Criteria Clin Chem. 2010;5(6):14452.
Janghorbani M, Amini M. Comparison of Fasting Glucose with Post-Load Glucose Values and Glycated Hemoglobin for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study Revi Diabet Stud, 2009;62(11):723.
Buse JB. Should Postprandial Glucose Be Routinely Measured and Treated to a Particular Target? No! Diabetes Care. 2003;26(5):16158.
Avignon A, Radauceanu A, Monnier L. Nonfasting plasma glucose is a better marker of diabetic control than fasting plasma glucose in type 2 diabetes. Diabetes Care. 1997;20(12):1822-6.
Nathan DM, Kuenen J, Borg R, Zheng H, Schoen-feld D, Heine RJ. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473.
Ketema EB, Kibret KT. Correlation of fasting and postprandial plasma glucose with HbA1c in assessing glycemic control; systematic review and meta-analysis. Arch Public Health. 2015;73:43.
Bonora E, Calcaterra F, Lombardi S, Bonfante N, Formentini G, Bonadonna RC, Muggeo M. Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: implications for treatment and monitoring of metabolic control. Diabetes Care. 2001;24(12):2023–2029.
El-Kebbi IM, Ziemer DC, Cook CB, Gallina DL, Barnes CS, Phillips LS. Utility of casual postprandial glucose levels in type 2 diabetes management. Diabetes Care. 2004;27(2):335-9.
Rohlfing CL, Wiedmeyer HM, Little RR, England JD, Tennill A, Goldstein DE. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care. 2002;25(2):275-8.
Prendergast C, Smyth O, Murray F, Cunningham SK, McKenna TJ. The relationship of blood glucose and haemoglobin A1 levels in diabetic subjects. Ir J Med Sci. 1994;163(5):233-5.
Bastyr EJ, 3rd, Stuart CA, Brodows RG, Schwartz S, Graf CJ, Zagar A, Robertson KE, IOEZ Study Group Therapy focused on lowering postprandial glucose, not fasting glucose, may be superior for lowering HbA1c. Diabetes Care. 2000;23(9):1236-41.
Levetan CS, Jeng LM, Thornton KR, Want L, Ratner RE. When do glucose values best correlate with hemoglobin A1c? Diabetes. 2001;50(2):124.