Liver and renal biochemical parameters in preeclampsia: a cross sectional study

Javid Ahmed Khan; Aadil Ashraf; Faizana Fayaz; Waseem Qureshi; Abu Talha Sheikh

doi:10.18203/2320-6012.ijrms20230575

Authors

Javid Ahmed Khan Department of Medicine, Government Medical College Srinagar, Jammu and Kashmir, India https://orcid.org/0000-0002-0699-2229
Aadil Ashraf Department of Gastroenterology, AIG Hospital, Hyderabad, Telangana, India
Faizana Fayaz Researcher, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, India
Waseem Qureshi Registrar Academics, Physician, Government Medical College Srinagar, Jammu and Kashmir, India
Abu Talha Sheikh Department of Medicine, Physician, Government Medical College Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230575

Keywords:

Liver function, Preeclampsia, Renal function

Abstract

Background: Pre-eclampsia is a multisystem disorder of human pregnancy with a genetic predisposition. It occurs more frequently in first pregnancies and leads to elevation in blood pressure and mainly affects maternal renal, cerebral, hepatic and clotting functions. This study evaluated biomarkers of renal and liver function among preeclamptic women.

Methods: This was a cross-sectional study conducted among 150 preeclamptic women and 150 normotensive healthy pregnant women in hospital. The baseline data comprising age, gestational age, and blood pressure were obtained. Serum urea, creatinine, and plasma levels of liver enzymes ALT and AST, total protein, albumin, globulin and glucose were measured.

Results: The plasma total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in urea creatinine, glucose, serum AST, and ALT activities in preeclamptic group.

Conclusions: Preeclampsia has harmful effects on renal and liver function as shown by alteration of these parameters.

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References

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