Evaluation of buprenorphine as an adjuvant to 2% lidocaine during intravenous regional anaesthesia

Yashoda Venkappa; Champa Banavara Venkatesha Murthy; Geetanjali Masamaddi; Sanchara M. Paramesh

doi:10.18203/2320-6012.ijrms20230164

Authors

Yashoda Venkappa Department of Anaesthesiology, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India
Champa Banavara Venkatesha Murthy Department of Anaesthesiology, Shimoga Institute of Medical Sciences, Shimoga, Karnataka, India
Geetanjali Masamaddi Department of Anaesthesiology, BGS Global Institute of Medical Sciences, Kengeri, Bangalore, Karnataka, India
Sanchara M. Paramesh Department of Anaesthesiology, Mysore Medical college and Research Institute; Mysore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230164

Keywords:

Bier’s block, Buprenorphine, Lidocaine, Tourniquet pain

Abstract

Background: Intravenous regional anaesthesia (IVRA) is a simple, effective method of anaesthesia for surgical procedures on the extremities. Major limitations are tourniquet pain, short duration of block and absence of post-operative analgesia. Buprenorphine is known to improve the quality of anaesthesia. Aim of this study is to evaluate the efficacy of buprenorphine as an adjuvant to lignocaine in IVRA.

Methods: Sixty patients between 18-60 years age, belonging to the ASA grade 1, 2 undergoing upper limb surgeries were enrolled into the study. Patients belonging to group BL patients received 10 ml of preservative free lidocaine 2% diluted to 40 ml. Group BB-patients received 10 ml of preservative free lidocaine 2% mixed with 60 mcg of buprenorphine diluted to 40 ml. Onset of sensory and motor block; recovery time and postoperative analgesia were noted. Data were analyzed using chi-square test, independent ‘t’ test.

Results: The onset time of both sensory and motor block were significantly shortened, the recovery of sensory and motor block was prolonged, the incidence of tourniquet pain was comparatively lesser and there was significantly increased duration of post-operative analgesia in the buprenorphine group. Haemo-dynamic parameters were similar in both groups

Conclusions: Sixty mcg buprenorphine as an adjuvant to lidocaine in IVRA effectively enhances the anaesthesia and post-operative analgesia.

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References

Jitendra M, Ashwani, Kumar, Jamwal A, Gupta H. Buprenorphine Significantly Prolongs Postoperative Analgesia in Intravenous Regional Anesthesia. JK Sci. 2015;17(3):114-7.

Ware RJ. Intravenous regional analgesia using bupivacaine-A double blind comparison with lignocaine. Anaesthesia. 1979;34:231-5.

Memis D, Turan A, Karamanlıog˘lu B, Pamukc UZ, Kurt I. Adding Dexmedetomidine to Lidocaine for Intravenous Regional Anesthesia. Anesth Analg. 2004;98:835-40.

Bansal A, Gupta S, Sood D, Kathuria S, Tewari A. Bier’s block using lignocaine and butorphanol. J Anaesthesiol Clin Pharmacol. 2011;27(4):465-9.

Gentili M, Bernard JM and Bonnet F. Adding Clonidine to Lidocaine for Intravenous Regional Anesthesia Prevents Tourniquet Pain. Anesth Analg. 1999;88:1327-30.

Turan A, Oglu BK, Memis D, Kaya G, Pamukc Z. Intravenous Regional Anesthesia Using Prilocaine and Neostigmine. Anesth Analg. 2002;95:1419-22.

Elgebaly A S.Does the Use of Nitroglycerin Patch Improve Local Anaesthetic Effects in Bier’s Block? A Double-Blind Placebo Controlled Study. Anesthesiol Res Pract. 2018;9674731:5.

Sen S, Ugur B, Aydın ON, Gursoy MO, Savk O. The Analgesic Effect of Nitroglycerin Added to Lidocaine on Intravenous Regional Anesthesia. Anesth Analg. 2006;102:916-20.

Dakhale GN, Hiware SK, Shinde AT, Mahatme MS. Basic biostatistics for post-graduate students. Indian J Pharmacol. 2012;44(4):435-42.

Sunder Rao PSS, Richard J. An Introduction to Biostatistics, A manual for students in health sciences, New Delhi: Prentice Hall of India. 4th edition. 2006;86-160.

Elenbaas, RM, Elenbaas, JK, Cuddy, PG. Evaluating the medical literature, part II: Statistical analysis. Ann Emerg Med. 1983;12:610-20.

Nilekani E, Menezes Y, D’Souza SA. A Study on the Efficacy of the Addition of Low Dose Dexmedetomidine as an Adjuvant to Lignocaine in Intravenous Regional Anaesthesia (IVRA). J Clin Diagnostic Res. 2016;10(10):UC01-5.

Tripathi KD. Essentials Of Medical Pharmacology, 7th edi, Jaypee Brothers Medical Publishers (P) Ltd.