A rare case of para-testicular dedifferentiated liposarcoma: a diagnostic dilemma

Biren P. Modi; Himanshu U. Patel

doi:10.18203/2320-6012.ijrms20230597

Authors

Biren P. Modi Department of Pathology, Nirali Cancer Hospital, Navsari, Gujarat, India
Himanshu U. Patel Department of Pathology, Nirali Cancer Hospital, Navsari, Gujarat, India https://orcid.org/0000-0002-3279-2263

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230597

Keywords:

Paratesticular, Liposarcoma, Spermatic cord, De-differentiated

Abstract

Paratesticular dedifferentiated liposarcoma (DD-LPS) are rare neoplasms. It has been estimated that 12% of DD-LPS occur in the paratesticular region, while the retroperitoneum is the most common site for this tumor. Herein, we presented a case of a 66-year-old male with a history of pedal edema and right scrotal swelling, CT scan shows a solid mass arising from the right side of the scrotum. Following this, a radical orchiectomy of the right testis with mass was performed, and after thorough microscopic and immunohistochemistry positive for MDM2 and CDK4, the diagnosis of low-grade dedifferentiated liposarcoma was given. This case report expands the morphologic spectrum of dedifferentiated liposarcoma and emphasizes the need to consider these tumours in the differential diagnosis of other neoplasms.

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References

Li Z, Zhou L, Zhao L, Chen P, Liu Y, Ding Y, et al. Giant paratesticular liposarcoma: A case report and review of the literature. Mol Clin Oncol. 2018;8(4):613-6.

Parra RD, Tavares LL, Gupta R, Silletti J, Shah A. Dedifferentiated liposarcoma of the scrotum. Case report and literature review. J Surg Case Rep. 2020;2020(9):rjaa342.

Goldblum JR, Folpe AL, Weiss SW. Liposarcoma. Enzinger and Weiss’s Soft Tissue Tumours. New York: Elsevier; 2020: 520-563.

Kryvenko ON, Rosenberg AE, Jorda M, Epstein JI. Dedifferentiated liposarcoma of the spermatic cord: a series of 42 cases. Am J Surg Pathol. 2015;39(9):1219-25.

Christopher DM, Bridge JA, Hogendoorn PCFM. Adipocytic Tumors. WHO Classification of Tumours of Soft tissue and Bone. Pathology. 2013;19-42.

Jason L, Hornick JSJB. Soft Tissue : Lesions of adipose tissue. Sternbergs Diagnostic Surgical Pathology. 2015;426-36.

Ghosh A, Swami R, Sen PK, Dwaka S. Unusual presentation of dedifferentiated liposarcoma as paratesticular mass. Indian J Pathol Microbiol. 2008;51(1):42-4.

Unlü Y, Huq GE, Ozyalvaçli G, Zengin M, Koca SB, Yücetas U, et al. Paratesticular sarcomas: A report of seven cases. Oncol Lett. 2015;9(1):308-12.

Chondros K, Heretis I, Papadakis M, Bozionelou V, Mavromanolakis E, Chondros N, et al. Dedifferentiated paratesticular liposarcoma with osseous metaplasia. Case Rep Urol. 2015;2015:965876.

Hatanaka K, Yoshioka T, Tasaki T, Tanimoto A. Paratesticular dedifferentiated liposarcoma with leiomyosarcomatous differentiation: a case report with a review of literature. Diagn Pathol. 2013;8:142.

Song JS, Gardner JM, Tarrant WP, Shen S, Ayala AG, Yu E, et al. Dedifferentiated liposarcoma with peculiar meningothelial-like whorling and metaplastic bone formation. Ann Diagn Pathol. 2009;13(4):278-84.