Frequency of venous thromboembolism during hajj sessions 2017-2019 in Makkah, Saudi Arabia
DOI:
https://doi.org/10.18203/2320-6012.ijrms20230849Keywords:
Makkah, Saudi Arabia, Venous thrombosisAbstract
Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE), both are serious health risks. In western countries, VTE affects about 114 to 184 people per 100,000. Asian populations have a significantly lower incidence than western populations. The true incidence of VTE is still not well documented in Saudi Arabia (KSA). There are different major risk factors especially in hajj season that predispose a person to thrombosis. The mortality rate of autopsy-based pulmonary embolism reaches up to 30%.
Methods: This single-centered retrospective descriptive study was done in security forces hospital Makkah, Saudi Arabia during hajj period (30 days) for consecutive three-year. All admitted confirmed DVT and PE patients (N=32) of both genders with age >14 years were included. Patients’ data were extracted from the electronic medical record. Data were analysed by SPSS version 23.
Results: Deep venous thrombosis (DVT) was developed in 67.7% while 19.3% of patients suffered from pulmonary embolism (PE) out of a total of 32 subjects. Females were more affected by 18 (56.3%) than males by 14 (43.8%). The mean age of patients was 51.78 years (SD ±16.21). A statistically significant association (p<0.005) between provoked VTE status and age, immobility, and history of surgery was seen. There was no mortality documented in this study.
Conclusions: This study provides insights into hajj period hospital admitted patients’ frequency of VTE, changing patient profiles, management strategies, and subsequent outcomes in patients with venous thromboembolism. There is a need for greater awareness of VTE prophylaxis about its prevention, especially in hajj season.
References
Ahmed H, Alzahrani RM, Alshardi IA, Aboulkhair AA, Alzahrani AB. Public perception to the knowledge of venous thromboembolism among Saudi Arabia 2020: a cross-sectional study. Med Sci. 2021;25(109):710-5.
Kahn SR, Lim W, Dunn AS. Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis: American College of chest physicians evidence-based clinical practice guidelines. Chest. 2012; 141(2):195-226.
Johnson SA, Eleazer GP, Rondina MT. Pathogenesis, diagnosis, and treatment of venous thromboembolism in older adults. J Am Geriatr Soc. 2016;64(9):1869-78.
Spencer FA, Gurwitz JH, Schulman S, Linkins LA, Crowther MA, Ginsberg JS, et al. Venous thromboembolism in older adults: a community-based study. Am J Med. 2014;127(6):530-7.
Deitelzweig SB, Johnson BH, Lin J, Schulman KL. Prevalence of clinical venous thromboembolism in the USA: current trends and future projections. Am J Hematol. 2011;86(2):217-20.
Hong J, Lee JH, Yhim HY, Choi WI, Bang SM, Lee H, et al. Incidence of venous thromboembolism in Korea from 2009 to 2013. PLoS One. 2018;13(1):e0191897.
Delluc A, Tromeur C, Le Ven F, Gouillou M, Paleiron N, Bressollette L, et al. Current incidence of venous thromboembolism and comparison with 1998: a community-based study in Western France. Thromb Haemost. 2016;116(5):967-74.
Fernandez MM, Hogue S, Preblick R, Kwong WJ. Review of the cost of venous thromboembolism. Clinicoecon Outcomes Res. 2015;7:451-62.
Chung WS, Lin CL, Sung FC, Hsu WH, Chen YF, Kao CH. Increased risks of deep vein thrombosis and pulmonary embolism in Sjögren syndrome: a nationwide cohort study. J Rheumatol. 2014;41(05):909-15
Lauber S, Limacher A, Tritschler T, Stalder O, Méan M, Righini M, et al. Predictors and outcomes of recurrent venous thromboembolism in elderly patients. Am J Med. 2018;131(6):703-16.
Mi Y, Yan S, Lu Y, Liang Y, Li C. Venous thromboembolism has the same risk factors as atherosclerosis: A PRISMA-compliant systemic review and meta-analysis. Medicine. 2016;95(32):4495
Stein PD, Kayali F, Olson RE, Milford CE. Pulmonary thromboembolism in Asians/Pacific islanders in the United States: analysis of data from the National Hospital Discharge Survey and the United States Bureau of the Census. Am J Med. 2004;116:435-42.
Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315-52.
Johnson SA, Eleazer GP, Rondina MT. Pathogenesis, diagnosis, and treatment of venous thromboembolism in older adults. J Am Geriatr Soc. 2016;64(9):1869-78.
Crowther MA, Kelton JG. Congenital thrombophilic states associated with venous thrombosis: a qualitative overview and proposed classification system. Ann Intern Med. 2003;138:128-34.
Schulman S, Lindmarker P, Holmström M, Lärfars G, Carlsson A, Nicol P, et al. Post‐thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months. J Thrombos Haemos. 2006;4(4):734-42.
Di Minno MN, Ambrosino P, Lupoli R, Di Minno A, Dentali F. Direct oral anticoagulants for the treatment of unprovoked venous thromboembolism: a meta-analysis of randomised controlled trials. Blood Transfus. 2015;13:391-5.
Luxembourg B, Schmitt J, Humpich M, Glowatzki M, Seifried E, Lindhoff-Last E. Intrinsic clotting factors in dependency of age, sex, body mass index, and oral contraceptives: definition and risk of elevated clotting factor levels. Blood Coagul Fibrinol. 2009;20:524-34.
AlSheef M, Alshammari FT, Alhawish MK, Alghamdi AG, Alqudhybi AF, Abu-Shaheen A. Clinical epidemiology of venous thromboembolic disease: An institutional registry. Front Cardiovasc Med. 2022;9:928094.
Al-Hameed FM, Al-Dorzi HM, Qadhi AI, Shaker A, Al-Gahtani FH, Al-Jassir FF, et al. Thromboprophylaxis and mortality among patients who developed venous thromboembolism in seven major hospitals in Saudi Arabia. Ann Thorac Med. 2017;12(4):282-89.
Lee LH, Gallus A, Jindal R, Wang C, Wu CC. Incidence of venous thromboembolism in asian populations: a systematic review. Thromb Haemost. 2017;117(12):2243-60.
Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrøm J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5(4):692-9.