Study of association of dry eye with diabetes mellitus
DOI:
https://doi.org/10.18203/2320-6012.ijrms20230312Keywords:
Dry eye, DM, TearAbstract
Background: Aim of the study was to evaluate the tear status in diabetes mellitus (DM) patient.
Methods: This study was a prospective observational case control study. Eighty patients with DM aged from 50 to 80 years were compared with a group of 80 normal healthy age matched control group. A general ophthalmological check-up was performed. The main points of comparison were subjective complaints, objective findings on basic Schirmer test, break-up time, Rose Bengal test.
Results: The results show that 27.5% of all diabetic subjects accompanied of dry eye symptoms, as against 6.25% of the control group. A mean BUT value was 15.5s and Standard Error was 0.20. In the control group mean BUT value was 14s and standard error was 0.23. Basic Schirmer test in DM group mean value was 9.50 mm and SE was 0.268. In the control group mean basic Schirmer test value was 15 mm and SE was 0.405. Rose Bengal test score in DM group, normal score (score <3) was found in 80% case and abnormal score (score >3) was found in 20%. In the control group, normal score was found in 93.75% and abnormal score was found in 6.25% case. Dry eye percentage in DM group 11.25% had definitive dry eye, 16.25% cases had possible dry eye and 72.5% cases had no dry eye. In control group 2.50% cases had definitive dry eye, 3.75% cases had possible dry eye and 93.75% had no dry eye.
Conclusions: The study shows that dry eye is associated with DM.
Metrics
References
Lemp MA, Foulks GN. Definition and classification of dry eye disease. Ocul Surf. 2007;5(2):75-92.
Foulks GN. Correlation between tear film lipid layer and dry eye disease. Survey of Ophthalmol. 2007;52(4):369-74.
Conrady CD, Joos ZP, Patel BC. Lacrimal gland and its role in dry eye. J Ophthalmology 2016;2016.
Sharma A, Hindman HB. Aging as a predisposition to dry eyes. J Ophthalmology 2014;2014.
American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(1): 62-69.
Zhang X, Zhao L, Deng S, Sun X, Wang N. Prevalence, etiology, and clinical characteristics of dry eye syndrome in diabetes mellitus patients. J Ophthalmol. 2016;2016.
Kaiserman I, Kaiserman N, Nakar S, Vinker S. Dry eye in diabetic patients. Am J Ophthalmol 2005;139(3):498-503.
Imam S, Elagin RB, Jaume JC. Diabetes-associated dry eye syndrome in new humanized transgenic model of type 1 diabetes. Molecular Vision. 2013;19:1259.
Fuerst N, Langelier N, Massaro-Giordano M, Pistilli M, Stasi K, Burns C et al. Tear osmolarity and dry eye symptoms in diabetics. Clin Ophthalmol (Auckland, NZ). 2014;8:507.
Manaviat MR, Rashidi M, Afkhami-Ardekani M, Shoja MR. Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol. 2008;8(1):10.
Lemp MA. Diagnosis and treatment of tear deficiencies. In: Tasman W, Jaeger EA, Schwab IR, Tessler HH (eds). Duane's Clinical Ophthalmology, vol 4. Revised ed. Philadelphia: Lippincott Williams and Wilkins. 2003;1-17.
Tseng SC, Tosubota K. Current concepts in ocular surface disease. Cornea and External Disease Congress, Gold Coast, Australia. 1993:10-12.
Hyndiuk RA, Kazarian EL, Schultz RO, Seideman S. Neurotrophic corneal ulcers in diabetes mellitus. Arch Ophthalmol. 1977;95(12):2193-6.
Schultz RO, Van Horn DL, Peter MA. Diabetic keratopathy. Trans Am Ophthalmol Soc. 1981;79:180-99.
Schultz RO, Peter MA, Sobocinski, Nassif K, Schultz KJ. Diabetic keratopathy as manifestation of peripheral neuropathy. Am J Ophthalmol. 1983;96:368-71.
Saini JS, Khandalavla B. Corneal epithelial fragility in diabetes mellitus. Can J Ophthalmol. 1995;30(3):142-6.
Dogru M, Katakami C, Inoue M. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology. 2001;108(3):586-92.
Van Bijsterveld OP. Diagnostic tests in sicca syndrome. Arch Ophthalmol. 1985;82(1):10.
Sanchez JC. The cornea in diabetes mellitus. Int Ophthalmol Clin. 1998;38(1):19-36.
Gilbard JP, Farris RL. Tear osmolarity and ocular surface disease in keratoconjunctivitis sicca. Arch Ophthalmol. 1979;97(9):1642-6.
Downloads
Published
How to Cite
Issue
Section
