Study of the prescription pattern of anti-depressants in a tertiary care hospital: a prospective observational study

Vishal A. Kulkarni; Mirza S. Baig; Prasad Deshpande

doi:10.18203/2320-6012.ijrms20230870

Authors

Vishal A. Kulkarni Department of Pharmacology, Government Medical College, Aurangabad, Maharashtra, India
Mirza S. Baig Department of Pharmacology, Government Medical College, Aurangabad, Maharashtra, India
Prasad Deshpande Department of Psychiatry, Government Medical College, Aurangabad, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230870

Keywords:

Drug utilization studies, Prescription patterns, WHO-DUS prescribing indicators, Generic names, SSRIs

Abstract

Background: One of the most important public health priorities are psychiatric disorders. Prescribing medications play a crucial role in providing good health care. Therefore, there is a need to understand prescription patterns at regular intervals.

Methods: This was a prospective, cross-sectional, observational study conducted at the psychiatry department OPD of Government Medical College, Aurangabad (Maharashtra, India) from January 2021 to June 2022. Records of prescriptions were collected from the hospital management information system.

Results: N=417 prescriptions were analysed. The male: female ratio was 1.25. Among total prescriptions analysed, selective serotonin reuptake inhibitors (SSRIs) were the most prescribed drug class (32.18%) followed by benzodiazepines (25.19%) and atypical antipsychotics (19.97%). Drugs prescribed as fixed dose combinations (FDC) were 2.10%. Most of the patients received polytherapy in which most patients constituted of two drug therapy (46.28%) and 34.53% of patients received monotherapy. In the patients managed by monotherapy, SSRIs were the most prescribed (29.16%), followed by atypical anti-psychotics (26.38%) and benzodiazepines (24.30%). Prescriptions with generic names were 93.12%. The average number of drugs per encounter was 1.88. Drugs prescribed from the essential drugs list (India) were 41.66%. Drugs prescribed from the essential medicines list (WHO) were 47%. The total number of prescriptions with injections 0.23%.

Conclusions: Prescribing patterns were according to the WHO-DUS parameters. Most patients were prescribed generic medicines. SSRIs, benzodiazepines and tricyclic antidepressants were the most prescribed drug class.

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References

Durga P, Abhinav P, Raj KV, Kishore P. Evaluation of Prescribing Patterns Using WHO Indicators at Out Patient Department of A Private Hospital in Warangal. IOSR J Pharm Biol Sci. 2017;12(03):01-4.

Summoro TS, Gidebo KD, Kanche ZZ, Woticha EW. Evaluation of trends of drug-prescribing patterns based on WHO prescribing indicators at outpatient departments of four hospitals in southern Ethiopia. Drug Des Devel Ther. 2015;4551.

Tejus A, Saxena SK, Dwivedi AK, Salmani MF, Pradhan S. Analysis of the prescription pattern of psychotropics in an outpatient department of a general hospital psychiatry unit. Med J Armed Forces India. 2022;78(1):74-9.

Thakkar KB, Jain MM, Billa G, Joshi A, Khobragade AA. A Drug Utilization Study of Psychotropic Drugs Prescribed in the Psychiatry Outpatient Department of a Tertiary Care Hospital. J Clin Diagn Res. 2013;7(12):2759-64.

Grover S, Avasth A, Kalita K, Dalal P, Rao G, Chadda R, et al. IPS multicentric study: Antidepressant prescription patterns. Indian J Psychiatry. 2013;55(1):41.

Grover S, Kumar V, Avasthi A, Kulhara P. An audit of first prescription of new patients attending a psychiatry walk-in-clinic in north India. Indian J Pharmacol. 2012;44(3):319-25.

Uchida N, Chong MY, Tan CH, Nagai H, Tanaka M, Lee MS, et al. International study on antidepressant prescription pattern at 20 teaching hospitals and major psychiatric institutions in East Asia: Analysis of 1898 cases from China, Japan, Korea, Singapore and Taiwan. Psychiatry Clin Neurosci. 2007;61(5):522-8.

Tripathi A, Avasthi A, Desousa A, Bhagabati D, Shah N, Kallivayalil R, et al. Prescription pattern of antidepressants in five tertiary care psychiatric centres of India. Indian J Med Res. 2016;143(4):507.

Luo Y, Kataoka Y, Ostinelli EG, Cipriani A, Furukawa TA. National Prescription Patterns of Antidepressants in the Treatment of Adults With Major Depression in the US Between 1996 and 2015: A Population Representative Survey Based Analysis. Front Psychiatry. 2020;11.

Bauer M, Monz BU, Montejo AL, Quail D, Dantchev N, Demyttenaere K, et al. Prescribing patterns of antidepressants in Europe: results from the Factors Influencing Depression Endpoints Research (FINDER) study. Eur Psychiatry. 2008;23(1):66-73.

Trivedi J, Dhyani M, Sareen H, Yadav V, Rai SB. Anti-depressant drug prescription pattern for depression at a tertiary health care center of Northern India. Med Pract Rev. 2010;1(2):16-8.

Ijcmr IJ of CMR. Socio-Demographic and Clinical Profile of Patients Suffering from Severe Depressive Disorders in Kashmir Valley. Available at: https://www.academia.edu/en/33361781/Socio_Demographic_and_Clinical_Profile_of_Patients_Suffering_from_Severe_Depressive_Disorders_in_Kashmir_Valley. Accessed on 12 January 2023.

Ghosh P, Barman S, Roy D, Roy S. Pattern of antidepressant prescription in patients suffering from depressive disorder in a tertiary care hospital. Int J Pharm Sci Res. 2022;13:942.

Jyotiranjan N, Prasanna SS, Priti D. Current Trends in Utilization of Antidepressants in a Tertiary Care Teaching Hospital: An Observational Study. IJCRR. 2021;13(15):127-32.

Chattar KB, Karve A, Subramanyam A, Tondare S. Prescription pattern analysis of antidepressants in psychiatric outpatient department of tertiary care hospital in India. Asian J Pharm Clin Res. 2016;9(4).

Laxmi P, Mounika S, Babu BJ, Kishore P. An Observational Study of drug use patterns in Depression patients in an Outpatient Department. J Med Sci Clin Res. 2019;7(9).

Mishra S, Trupti S, Mohanty M. Patterns of prescription & efficacy evaluation of Antidepressants in a tertiary care teaching hospital in Eastern India. Asian J Pharm Clin Res. 2012;5:193-6.

Mohan P, Singh H, Sinha S, Prabhakaran K. Pharmacological profile of prescriptions containing antidepressants. J Marine Med Soc. 2021;23(1):29-32.

Venkataraman R, Rayamajhi M, Islam S. Prescribing pattern of psychotropic agents in rural tertiary care teaching hospital. Asian J Pharm Clin Res. 2018;11(3):155.

Lahon K, Shetty HM, Paramel A, Sharma G. A retrospective drug utilization study of antidepressants in the psychiatric unit of a tertiary care hospital. J Clin Diagnost Res. 2011;5:1069-75.