Proficiency of platelet parameters as an inexpensive efficient early marker for diagnosis of neonatal sepsis


  • Nilay Ranjan Bagchi Department of Pediatrics, North Bengal Medical College and Hospital, Sushrutanagar, Darjeeling, West Bengal, India



Thrombocytopenia, MPV, P-LCR, MPV/TPC, Sepsis, Neonate


Background: Neonatal sepsis is an invasive serious infection which is life threatening if not treated early. Though blood culture is the gold standard for diagnosis but it yields positive results in fewer number of cases and it also time consuming. So it is requisite to ordain a cost effective and easy marker for its early diagnosis to initiate treatment to reduce the case fatality.

Methods: A prospective study was done for 12 months upon 48 blood culture proven cases of neonatal sepsis. 48 normal babies were taken as control group. Platelet parameters were studied in all 96 babies of the study population.

Results: It was found that thrombocytopenia, mean platelet volume (MPV), platelet large cell ratio (P-LCR) and mean platelet volume to total platelet count ratio (MPV/TPC) are early helpful markers for diagnosis of sepsis in neonates with p value of 0.0003, <0.0001, <0.0001 and <0.0001 respectively. MPV/TPC has the highest specificity (95.6%) with positive predictive value (90.2%).

Conclusions: Platelet count and its indices are cheap, early and workable marker for diagnosis of neonatal sepsis.


World Health Organization. Level and trends in child mortality report. Available at: news-room/fact-sheet/detail/level-and-trends-in-child-mortaliry-report-2021. Accessed on 06 January 2023.

UNICEF. Newborn and child health. Available at: Accessed on 06 January 2023.

Sarangi KK, Pattanaik D, Mishra SN, Nayak MK, Jena J. Bacteriological Profile and antibiogram of blood culture isolates done by automated culture and sensitivity method in a neonatal intensive care unit in a tertiary care hospital in Odisha, India. Int J Adv Med. 2015;2(4):487-92.

Ansari S, Nepal HP, Gautam R, Shrestha S, Neopane P, Chapagain ML. Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset. Int J Pediatr. 2015;379806.

Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn JE, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430-40.

Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2):285-91.

NNPD Network. National Neonatal-Perinatal Database: Report 2002-2003.2005. Available at : Accessed on 06 January 2023.

Office of the Registrar General & Census Commissioner,India. SRS stastistical report 2013. Available at : Accessed on 06 January 2023.

Hornik CP, Benjamin DK, Becker KC, Benjamin DK, Li J, Clark RH, et al. Use of complete blood cell count in late-onset sepsis. Pediatr Infect Dis J. 2012:31(8):803-7.

Michel M, Brown LS and Rosenfield CR. Serial neutrophil values facilitate predicting the absence of neonatal early-onset sepsis. J Pediatr. 2014;164930:522-8.

Schelonka RL, Yoder BA, Desjardins SE, Hall RB, Butler J. Peripheral leucocyte count and leucocyte indexes in healthly newborn term infants. J Pediatr. 1994;125:603-6.

Da Silva O, Ohlsson A, Kenyon C. Accuracy of leucocyte indices and C-reactive protein for diagnosis of neonatal sepsis: A critical review. Pediatr Infect Dis J. 1995;14:362-6.

Stevenson EK, Rubenstein AR, Radin GT. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42(3):625-31.

Van der Lelie J,Von dem Borne AK. Increased mean platelet volume in septicemia. J Clin Pathol. 1983;36:693-6.

O'Connor TA, Ringer KM, Gaddis ML. Mean platelet volume during coagul-negative staphylococcal sepsis in neonates. Am J Clin Pathol. 1993;99:69-71.

Storm W. Use of thrombocytopenia for early identification of sepsis in critically ill newborns. Acta Paediatr Acad Sci Hung 1982;23:349-55.

Sayed HM, Shabnam A, Sedigheh K. Platelet indices as useful indicators of neonatal sepsis. J Evol Med Dent Sci. 2019;8(20):1612-7.

Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci. 2013;13(2):333-8.

Choudhary RR, Makwana M, Mourya HK. Evaluation of platelet and its indices as a marker of neonatal sepsis : a prospective case control study. IJCP. 2018;5(5):1898-903.

Fitzgerald JR, Foster TJ, Cox D. The interaction of bacterial pathogen with platelets. Nat Rev Microbiol. 2006;4(6):445-57.

Mittal A, Arya S, Charan LS, Saluja S. Elevation of platelet indices as additional diagnostic tool for neonatal sepsis. Astrocyte. 2018;4:205-9.

Bhat SA, Naik SA, Rafiq W, Sayed Tariq A. Incidence of Thrombocytopenia and changes in various Platelet parameter in neonates with blood culture positive sepsis. Int J Pediatr. 2015;3:757-66.

Majumder A, Biswas S, Jana A. Platelet indices as an earlier and economical marker of neonatal sepsis. Iraqi J Hematol. 2021;10:108-11.

Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clin Chem. 1997;43:1072-6.

Ustundag Budak Y, Potal M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery:a systemic review. Biochemia Medica. 2016;26(2):178-93.

Panda SK, Nayek MK, Thangaraj J. Platelet parameters as a diagnostic marker in early diagnosis of neonatal sepsis-Seeking newer answers for older ploblems. J Family Med Prim Care. 2022;11:1748-54.




How to Cite

Bagchi, N. R. (2023). Proficiency of platelet parameters as an inexpensive efficient early marker for diagnosis of neonatal sepsis. International Journal of Research in Medical Sciences, 11(4), 1257–1261.



Original Research Articles