Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition

Authors

  • Mukta Waghmare Department of Paediatric Surgery, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, Maharashtra
  • Hemanshi Shah Department of Paediatric Surgery, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, Maharashtra
  • Vikrant Kumbhar Department of Paediatric Surgery, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, Maharashtra
  • Shalika Jayaswal Department of Paediatric Surgery, T.N.M.C and B.Y.L. Nair Hospital, Mumbai, Maharashtra

DOI:

https://doi.org/10.18203/2320-6012.ijrms20162339

Keywords:

Van Wyk Grumbach, Hypothyroidism, Pre-pubertal girls, Ovarian cysts

Abstract

Van Wyk Grumbach syndrome is a sequel of long standing untreated primary hypothyroidism. It occurs in both sexes. In boys, it is associated with testicular enlargement. Girls present with features of early onset menarche, enlarged bilateral multicystic ovaries and delayed skeletal growth. Prompt replacement therapy with Thyroxine corrects the menstrual abnormality and the ovaries also return to normal over a period of time. We describe an unusual case of irregular vaginal bleeding, giant bilateral ovarian cysts and delayed bone age in a young girl due to severe hypothyroidism who promptly responded to levo-thyroxine.

References

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Published

2017-01-04

How to Cite

Waghmare, M., Shah, H., Kumbhar, V., & Jayaswal, S. (2017). Van Wyk Grumbach syndrome - a rare association of a common prepubertal condition. International Journal of Research in Medical Sciences, 4(8), 3616–3618. https://doi.org/10.18203/2320-6012.ijrms20162339

Issue

Section

Case Reports