Diagnostic utility of bone marrow aspiration in bicytopenia

Silvi Sandhu; Arundhati Vaid; Ruchi Khajuria; Ameet Kaur; Ayushi Sharma

doi:10.18203/2320-6012.ijrms20230680

Authors

Silvi Sandhu Department of Pathology, Government Medical College Jammu, Jammu and Kashmir, India
Arundhati Vaid Department of Pathology, Government Medical College Jammu, Jammu and Kashmir, India
Ruchi Khajuria Department of Pathology, Government Medical College Jammu, Jammu and Kashmir, India
Ameet Kaur Department of Pathology, Government Medical College Jammu, Jammu and Kashmir, India
Ayushi Sharma Department of Pathology, Government Medical College Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20230680

Keywords:

Bicytopenias, Bone marrow aspiration, Hematological malignancies, Non hematological malignancy

Abstract

Background: Haematological diseases are frequently seen now a days in different age groups. Patients can present with a variety of presentations in form of cytopenia of a single lineage or in a dual combination or with pancytopenia. Our study focusses on the utility of bone marrow aspiration for diagnosis of bicytopenias by assessment of pattern of bicytopenias in peripheral smear examination.

Methods: This was a retrospective study that was conducted over a period of one year in a tertiary care institute of Northern India. Cases of bicytopenia were subjected to bone marrow aspiration and parameters such as cellularity, myeloid to erythroid ratio and cytomorphological details of the cells were documented.

Results: Study consisted of male predominance with maximum patients in the age group of 21-30 years. Most common bicytopenia was found to be anaemia with thrombocytopenia and normoblastic erythroid hyperplasia was the most common aetiology.The results of this study were similar to those in the earlier literature with the inference that bone marrow aspiration performed for all cases significantly helped in arriving at the diagnosis.

Conclusions: Bicytopenia is a good haematological indicator for many non-malignant and malignant diseases. Knowledge of its aetiologies can help in the diagnosis and efficient management of patients. Bone marrow study forms a cost-effective tool in interpretation of bicytopenia.

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References

Singh A, Hungund B, Kumar L, Pattanshetti M. Clinico-haematological profile of patients with bicytopenia. Pathology. 2018;50(5):540-8.

Thakur R, Kaur N, Arjun M, Sanjeevan S, Pankaj P, Velu N. Clinicohematological profile of patients with peripheral blood cytopenias in clinical practice. Iraqi J Hematol. 2019; 8(1):1-6.

Saadia HD, Muhammad Muhammad S, Amreek L, Rashid A. Incidentally diagnosed bicytopenia showing a wide spectrum of pathologies on bone marrow morphology. KJMS. 2015;8(2):247-50.

Desalphine M, Bagga PK, Gupta PK, Kataria AS. To evaluate the role of bone marrow aspiration and bone marrow biopsy in pancytopenia. J Clin Diagnostic Res. 2014;8(11):FC11-5.

Rajesh P, Shailaja P. Pancytopenia-a study of 58 cases. J Evolution Med Dental Sci. 2013;2(45):8724-8.

Athar R, Khonglah Y, Raphael V, Pal A, Lynrah KG. Clinico-hematologic and biochemical profile of dimorphic anaemia with bone marrow study. Internet J Lab Med. 2014;6:01-8.

Saira PI, Ghulam NK, Saleem PI. Vitamin B12 deficiency-A major cause of megaloblastic anaemia in patients attending a tertiary care hospital. J Ayub Med Coll Abbottabad. 2009;21(3):92-4.

Ekwere TA, Ino-Ekanem MB, Motilewa OO. Indications and spectrum of haematological disorders from bone marrow aspiration examination: A three year review study. Global J Hematol Blood Transfusion. 2015;2(1):04-8.

Niazi M, Fazal-e-Raziq, Khan MT. Clinical and hematological features of megaloblastic anaemia alone or in combination with iron deficiency anaemia–An analysis of 349 patients. J Med Sci. 2009;17(2):81-4.

Singh I, Jain R, Gupta GN, Goyal PK. Evaluation of bone marrow for hematological anomalies in Indian pediatric and adult patients: A single tertiary care center study. Int J Pharmaceutical Sci Res. 2015;6(4):1585- 9.

Choudhary PK, Sing SK, Basnet RB. Study of megakaryocytes in bone marrow aspiration smears in patients with thrombocytopenia. J Pathol Nepal. 2013;3(6):476-81.

Sengupta M, Saha K, Chetna JM. Bone marrow aspiration study in thrombocytopenia. Int J Scientific Res. 2012;1(7):136-9.

Nigam RK, Chaudhary R, Malik R, Gour D, Shrivastava A, Tripathi A et al. Pancytopenia--clinico-haematological studies of bone marrow examination. J Evolution Med Dental Sci. 2013;2(47):9213-9.

Anjum MU, Nargis Noman, Shah SH, Khaliq MA. Spectrum of hematological disorders on bone marrow aspirate examination. Gomal J Med Sci. 2014;12(4):193-6.

Miller CE, Bain BJ. The utility of blood and bone marrow films and trephine biopsy sections in the diagnosis of parasitic infections. Mediterr J Hematol Infect Dis. 2015;7(1):e2015039.

Patel J, Popat VC. Spectrum of hematological disorders observed in consecutive 150 cases on bone marrow examination. Int J Res Med. 2014;3(2):139-41.

Tilak V, Das S, Bundhun S. Value of bone marrow imprint smears in early diagnosis of bone marrow pathologies. J Clin Diagn Res. 2014;8(11):FC01-03.