Vitamin D and sleep duration: a possible link
DOI:
https://doi.org/10.18203/2320-6012.ijrms20231329Keywords:
Sleep duration, Vitamin DAbstract
Background: Normal-range sleep duration is an important factor for general health and metabolism. Insufficient or excessive sleep duration is associated with various chronic physical or mental illness, such as obesity, hypertension, diabetes, metabolic syndrome, depression, and other psychiatric diseases. Sleep duration is mainly affected by circadian rhythm, and circadian rhythm is affected by the melatonin level controlled by the light exposure. Therefore, sun exposure has an important role for determining sleep time. Aim and objective was to find an association between self-reported sleep duration with serum vitamin D levels in healthy adults.
Methods: A cross sectional study was carried out on 150 first professional MBBS students. They were asked about their sleep duration via a questionnaire and their morning samples of serum vitamin D was taken. All the data was put in SPSS software and analyzed.
Results: There was a definite positive correlation between sleep duration and the concentration of 25(OH)D in this study (r=0.11, p<0.05).
Conclusions: The present study revealed that vitamin D [25(OH)D] deficiency was an independent predictor of insufficient sleep among healthy adults.
Metrics
References
de Oliveira DL, Hirotsu C, Tufik S, Andersen ML. The interfaces between vitamin D, sleep and pain. J Endocrinol. 2017;234(1):R23-36.
Huiberts LM, Smolders Karin CHJ. Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway. Sleep Med Rev. 2021;55:101379.
Bertisch SM, Sillau S, deBoer Ian H, Szklo M, Redline S. 5-hydroxyvitamin D concentration and sleep duration and continuity: multi-ethnic study of atherosclerosis. Sleep. 2015;38(8):1305-11.
Kim JH, Chang JH, Kim DY, Kang JW. Association between self-reported sleep duration and serum vitamin D level in elderly Korean adults. Am Geriatr Soc. 2014;62:2327-32.
Liu X, Ke L, Ho J, Abboud M, Mpofu E, Brennan-Speranza TC, et al. Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study. Plos One. 2020;15(3):e0229642.
Choi JH, Lee B, Lee JY, Kim CH, Park B, Kim DY, et al. Relationship between sleep duration, sun exposure, and serum 25-hydroxyvitamin D status: a cross-sectional study. Scient Rep. 2020;10:4168.
Mosavat M, Smyth A, Arabiat D, Whitehead L. Vitamin D and sleep duration: Is there a bidirectional relationship? Hormone Mole Biol Clin Investig. 2020;41(4).
Abboud M. Vitamin D supplementation and sleep: a systematic review and meta-analysis of intervention studies. Nutrients. 2022;14(5):1076.
Archontogeorgis K, Nena E, Steiropoulos P. Linking Vitamin D and Sleep. In: Neurological Modulation of Sleep Mechanisms and Function of Sleep Health. Elsevier; 2020:385-399.
Muscogiuri G, Barrea L, Scannapieco M, Somma CD, Scacchi M, Aimaretti G, et al. The lullaby of the sun: the role of vitamin D in sleep disturbance. Sleep Med. 2019;54:262-5.
Romano F, Mucogiuri G, Benedetto ED, Zhukouskaya VV, Barrea L, Savastano S, et al Vitamin D and sleep regulation: is there a role for vitamin D? Curr Pharm Design. 2020;26(21):2492-6.
Fu X, Zhao X, Lu H, Jiang F, Ma X, Zhu S. Association between sleep duration and bone mineral density in Chinese women. Bone. 2011;49(5):1062-6.
Bel S, Michels N, Vriendt TD, Patterson E, Garcia MC, Diethelm K, et al. Association between self-reported sleep duration and dietary quality in European adolescents. Br J Nutr. 2006;110(5):949-59.
Gao Qi, Kou T, Zhuang B, Ren Y, Dong X, Wang Q. The association between vitamin D deficiency and sleep disorders: a systematic review and meta-analysis. Nutrients. 2018;10(10):1395.
Andersen ML, Tufik S. Vitamin D as an underlying factor in sleep-related issues. J Clin Sleep Med. 2012;8:699.
Al-Shawwa B, Ehsan Z, Ingram DG. Vitamin D and sleep in children. J Clin Sleep Med. 2020;16:1119-23.
Stumpf WE, O’Brien LP. 1,25(OH)2 vitamin D3 sites of action in the brain. An autoradiographic study. Histochemistry. 1987;87:393-406.
Yan S, Tian Z, Zhao H, Wang C, Pan Y, Yao N et al. A meta-analysis: Does vitamin D play a promising role in sleep disorders? Food Sci Nutr. 2020;8:5696-709.
Egierska D, Pietruszka P, Burzynska P, Chruscicka I, Buchta J. Pleiotropic effects of vitamin D3. J Educ Health Sport. 2021;11:143-55.
Prono F, Bernardi K, Ferri R, Bruni O. The role of vitamin D in sleep disorders of children and adolescents: a systematic review. Int J Mol Sci. 2022;23(3):1430.